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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN
This study was carried to explore the involvement of circZNF652 in OA. RT-qPCR was performed to analyse the expression of circZNF652 and PTEN mRNA in synovial fluid samples from 60 OA patients and 60 healthy controls. Correlations between circZNF652 and PTEN mRNA were analysed by Pearson's correlation coefficient. Overexpression and siRNA silencing of circZNF652 were achieved in chondrocytes, followed by performing RT-qPCR and Western blot to analyse the expression of PTEN. The role of circZNF652 and PTEN in regulating the apoptosis of chondrocytes induced by LPS was analysed by cell apoptosis assay. We found that circZNF6...
Source: Autoimmunity - July 15, 2021 Category: Allergy & Immunology Authors: Xuefeng Yuan Yingchi Zhang Cong Cai Chaoxu Liu Jie Xie Chengla Yi Source Type: research
Simultaneous blockade of TIGIT and HIF-1 α induces synergistic anti-tumor effect and decreases the growth and development of cancer cells
CONCLUSIONS: Present data suggest the combination treatment of TIGIT and HIF-1α as a novel treatment strategy against colorectal and breast cancer, but more researches are required to realize the complete role of TIGIT and HIF-1α inside the TME.PMID:34710844 | DOI:10.1016/j.intimp.2021.108288
Source: International Immunopharmacology - October 28, 2021 Category: Allergy & Immunology Authors: Mehrdad Fathi Simin Bahmanpour Asal Barshidi Hossein Rasouli Fariba Karoon Kiani Armin Mahmoud Salehi Khesht Sepideh Izadi Bentolhoda Rashidi Shiva Kermanpour Roya Mokhtarian Vahid Karpisheh Hadi Hassannia Hamed Mohammadi Ali Jalili Farhad Jadidi-Niaragh Source Type: research
The mixture of siRNAs targeted to IL-4 and IL-13 genes effectively reduces the airway hyperreactivity and allergic inflammation in a mouse model of asthma
In this study we evaluated whether the siRNA targeted to IL-4 and IL-13 reduce BA symptoms in mice model. Experimental BA was induced in BALB/c mice by sensitization to ovalbumin allergen followed by intranasal challenge. The intranasal delivery of siRNAs targeted to IL-4 and IL-13 inhibited the lung expression of these cytokines by more than 50% that led to the attenuation of AHR and pulmonary inflammation; the quantity of eosinophils in lungs which are one of the major inflammatory cells involved in allergic asthma pathogenesis decreased by more than 50% after siRNA treatment. These data support the possibility of a dual...
Source: International Immunopharmacology - December 19, 2021 Category: Allergy & Immunology Authors: Shilovskiy Ip Sundukova Ms Korneev Av Nikolskii Aa Barvinskaya Ed Kovchina Vi Vishniakova Li Turenko Vn Yumashev Kv Kaganova Mm Brylina Ve Sergeev I Maerle A Kudlay DA Petukhova O Khaitov M R Source Type: research
Kindlin-2 Mediates Lipopolysaccharide-Induced Acute Lung Injury Partially via Pyroptosis in Mice
In this study, we found that the concentration of kindlin-2 was elevated in the lungs of ALI mice. The specific deletion of kindlin-2 by kindlin-2 siRNA attenuated the severity of lung injury, which was demonstrated by the reduced number of pro-inflammatory cells in bronchoalveolar lavage fluid and lung wet/dry weight ratio, and ameliorated pathologic changes in the lungs of ALI mice. Furthermore, kindlin-2 siRNA decreased the mRNA levels of pro-inflammatory factors (IL-1 β, IL-6, and TNF-α) and the protein levels of pyroptosis-related proteins. In vitro studies confirmed that LPS + ATP promoted the expressions of p...
Source: Inflammation - February 8, 2022 Category: Allergy & Immunology Source Type: research
Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis
CONCLUSION: Circ_0072088 elicited oncogenic role in malignant cell progression and glycolysis of PDAC cells through circ_0072088/miR-545-3p/SLC7A11 pathway.HighlightsCirc_0072088 was upregulated in PDAC tumours and was associated with high tumour burden.Blocking circ_0072088 suppressed cell proliferation, migration, invasion, and glycolysis in PDAC cells.Circ_0072088 could directly regulate miR-545-3p, and SLC7A11 was a target of miR-545-3p.Restoring miR-545-3p mimicked the effects of circ_0072088 knockdown in PDAC cell in vitro.PMID:35166634 | DOI:10.1080/08916934.2022.2027919
Source: Autoimmunity - February 15, 2022 Category: Allergy & Immunology Authors: Hui Sun Fang Liu Hongqing Zhang Source Type: research
