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Total 1918 results found since Jan 2013.

Socioeconomic Disparities in the Economic Impact of Childhood Food Allergy
CONCLUSIONS: Disparities exist in the economic impact of food allergy based on socioeconomic status. Affordable access to specialty care, medications, and allergen-free foods are critical to keep all food-allergic children safe, regardless of income and race.
Source: PEDIATRICS - May 1, 2016 Category: Pediatrics Authors: Bilaver, L. A., Kester, K. M., Smith, B. M., Gupta, R. S. Tags: Allergy/Immunology Article Source Type: research

Anaphylactic Reactions to Novel Foods: Case Report of a Child With Severe Crocodile Meat Allergy
In this report, we describe the first case of anaphylaxis to crocodile meat. The patient was a 13-year-old boy with severe immunoglobulin E–mediated allergy to chicken meat. When tasting crocodile meat for the first time, he developed an anaphylactic reaction. Cross-reactivity between chicken and crocodile meat was suspected to have triggered this reaction. Basophil activation and immunoglobulin E testing confirmed the boy’s allergic reaction to crocodile meat proteins. Molecular analysis identified a crocodile α-parvalbumin, with extensive sequence homology to chicken α-parvalbumin, as the main cro...
Source: PEDIATRICS - March 31, 2017 Category: Pediatrics Authors: Ballardini, N., Nopp, A., Hamsten, C., Vetander, M., Melen, E., Nilsson, C., Ollert, M., Flohr, C., Kuehn, A., van Hage, M. Tags: Allergy/Immunology Case Report Source Type: research

Recent developments in understanding the mechanisms of food allergy
Purpose of review The prevalence of food allergy is rising globally. This review will discuss recent discoveries regarding the immunologic mechanisms that drive the initial sensitization and allergic response to food antigens, which may inform prevention and treatment strategies. Recent findings Tolerance to food antigens is antigen-specific and promoted by oral exposure early in life and maternal transfer of immune complexes via breast milk. IgG can inhibit both the initiation and effector phases of allergic responses to food antigens in mice, and high levels of food-specific IgG4 are associated with acquisition of t...
Source: Current Opinion in Pediatrics - November 7, 2019 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

COVID-19 mRNA vaccine allergy
Purpose of review A known history of a severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine is the only contraindication to coronavirus disease 2019 (COVID-19) mRNA vaccination. It is important for pediatricians to understand the likelihood of an allergic reaction to COVID-19 mRNA vaccines, including its excipients. Recent findings Episodes concerning for anaphylaxis were immediately reported following early administration of COVID-19 mRNA vaccines to adults. Although allergic type symptoms were reported equally in recipients of placebos and test vaccines in phase 3 clinical trials, post-...
Source: Current Opinion in Pediatrics - November 10, 2021 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Mislabelled cow's milk allergy in infants: a prospective cohort study
Conclusions Mislabelled CMA typically presents within the first 3 months of life involving a single organ. Infant AD and higher parental academic education are associated with mislabelled reactions. Better parental and physician awareness of the importance of objectively diagnosing milk allergy is required to avoid mislabelling of infants as being allergic to cow's milk and to prevent potential nutritional deficiencies.
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Elizur, A., Cohen, M., Goldberg, M. R., Rajuan, N., Katz, Y. Tags: Epidemiologic studies, Immunology (including allergy), Dermatology Original article Source Type: research

Diagnosis and management of food allergy in children
Food allergy (FA) in children is common, affecting about 6% of children in the UK, and is thought to be increasing in prevalence. Presentation varies widely with age, causative food, type of FA (IgE-mediated or non-IgE mediated) and severity. Assessment of suspected FA includes a detailed clinical history and dietary history and appropriate confirmatory allergy testing. The traditional management of complete dietary exclusion of the causative and related foods is evolving to one of limiting exclusion and early reintroduction.
Source: Paediatrics and Child Health - March 17, 2016 Category: Pediatrics Authors: David Luyt, Heidi Ball, Kerrie Kirk, Gary Stiefel Tags: Symposium: allergy Source Type: research

An update on oral immunotherapy for the treatment of food allergy
Food allergy is an important public health concern, affecting 10% of infants, 5–6% of children and 2% of adults in westernized countries. Current management involves food avoidance, education of patients and carers in the emergency management of allergic reactions and in some cases provision of an adrenaline autoinjector. Oral immunotherapy (OIT) has recently been explored as a potential treatment for food allergy. This review will discuss mechanisms of oral tolerance and summarize clinical and immunologic effects of OIT.
Source: Paediatrics and Child Health - April 12, 2016 Category: Pediatrics Authors: Mimi L.K. Tang, Kuang-Chih Hsiao Tags: Symposium: allergy Source Type: research

Does Giving Infants Peanut Lower Their Peanut Allergy Risk? Does Giving Infants Peanut Lower Their Peanut Allergy Risk?
Introducing infants to peanut may not lower their risk for peanut allergy, researchers in Australia suggest.Medscape Medical News
Source: Medscape Pediatrics Headlines - July 13, 2022 Category: Pediatrics Tags: Allergy & Clinical Immunology News Source Type: news

An extensively hydrolysed rice protein-based formula in the management of infants with cow's milk protein allergy: preliminary results after 1 month
Conclusions In accordance with current guidelines, this eRHF is tolerated by more than 90% of children with proven CMPA with a 95% CI, and is an adequate alternative to cow's milk-based eHF. Trial registration number ClinicalTrials.gov NCT01998074.
Source: Archives of Disease in Childhood - September 11, 2014 Category: Pediatrics Authors: Vandenplas, Y., De Greef, E., Hauser, B., Paradice Study Group, Halut, Robberecht, Balduck, l'Homme, Mohring, Carvelli, Hauser, Defontaine, Questiau, Christens, Henckens, Lemmens, Vercammen, De Greef Tags: Open access, Immunology (including allergy), Childhood nutrition, Infant nutrition (including breastfeeding) Original article Source Type: research

Active management of food allergy: an emerging concept
IgE-mediated food allergies are common and currently there is no cure. Traditionally, management has relied upon patient education, food avoidance and the provision of an emergency medication plan. Despite this, food allergy can significantly impact on quality of life. Therefore, in recent years, evolving research has explored alternative management strategies. A more active approach to management is being adopted, which includes early introduction of potentially allergenic foods, anticipatory testing, active monitoring, desensitisation to food allergens and active risk management. This review will discuss these areas in turn.
Source: Archives of Disease in Childhood - March 17, 2015 Category: Pediatrics Authors: Anagnostou, K., Stiefel, G., Brough, H., du Toit, G., Lack, G., Fox, A. T. Tags: Patients, Immunology (including allergy) Review Source Type: research

Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children
CONCLUSIONS: These prepubertal children with persistent CMA had lower lumbar spine BMD z scores than children with NCMA, which likely resulted from lower calcium intake.
Source: PEDIATRICS - May 1, 2016 Category: Pediatrics Authors: Mailhot, G., Perrone, V., Alos, N., Dubois, J., Delvin, E., Paradis, L., Des Roches, A. Tags: Nutrition, Allergy/Immunology Article Source Type: research

Indoor Environmental Control Practices and Asthma Management
Indoor environmental exposures, particularly allergens and pollutants, are major contributors to asthma morbidity in children; environmental control practices aimed at reducing these exposures are an integral component of asthma management. Some individually tailored environmental control practices that have been shown to reduce asthma symptoms and exacerbations are similar in efficacy and cost to controller medications. As a part of developing tailored strategies regarding environmental control measures, an environmental history can be obtained to evaluate the key indoor environmental exposures that are known to trigger a...
Source: PEDIATRICS - October 31, 2016 Category: Pediatrics Authors: Matsui, E. C., Abramson, S. L., Sandel, M. T., SECTION ON ALLERGY AND IMMUNOLOGY, COUNCIL ON ENVIRONMENTAL HEALTH Tags: Allergy/Immunology, Asthma From the American Academy of Pediatrics Source Type: research

Use of Food Allergy Panels by Pediatric Care Providers Compared With Allergists
CONCLUSIONS: Review of food allergen IgE testing through a high volume outpatient laboratory revealed PCPs order significantly more food allergen panels, tests for uncommon causes of food allergy, and generate higher cost per patient compared with allergists. These results suggest a need for increased education of PCPs regarding proper use of food IgE tests.
Source: PEDIATRICS - November 30, 2016 Category: Pediatrics Authors: Stukus, D. R., Kempe, E., Leber, A., Thornton, D., Scherzer, R. Tags: Allergy/Immunology Article Source Type: research

The overlap between allergy and immunodeficiency
Purpose of review The mechanisms underlying the overlap of, and relationship between, atopy and immunodeficiency are just beginning to be recognized, through the identification of novel genetic conditions and the reexamination of well known primary immunodeficiencies. The present review seeks both to frame the topic and to highlight the most recent literature combining allergy in the context of immunodeficiency. Recent findings The true prevalence of atopic disorders in the setting of primary immunodeficiency as a whole is difficult to pinpoint, however there have been recent attempts to measure prevalence. Individual...
Source: Current Opinion in Pediatrics - November 10, 2018 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Henry H. Bernstein Source Type: research

Cow's milk protein allergy
(CMPA) is caused by a reproducible immune-mediated response to milk proteins and tends to present during the first few months of life. This response can vary significantly from an immediate reaction within 2 hours of ingestion to a more delayed reaction, which can occur anywhere between 2 and 72 hours later. A delay in diagnosis can cause significant child and parental distress, while overdiagnosis can lead to an unnecessary elimination diet. CMPA can be confused with lactose intolerance which is a non-immune mediated response as a result of lactase enzyme deficiency.
Source: Paediatrics and Child Health - May 9, 2020 Category: Pediatrics Authors: Amrit Dhesi, Gillian Ashton, Maria Raptaki, Nick Makwana Tags: Symposium: allergy Source Type: research