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Diagnosis and management of asthma, COPD and asthma ‐COPD overlap among primary care physicians and respiratory/allergy specialists: a global survey
ConclusionWhile most PCPs and respiratory/allergy specialists can reach a working diagnosis of ACO, there remains uncertainty around which diagnostic features are most important and what constitutes optimal management. It is imperative that clinical studies including patients with ACO are initiated, allowing the generation of evidence ‐based management strategies.This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - March 1, 2019 Category: Respiratory Medicine Authors: Christine Jenkins, J. Mark FitzGerald, Fernando J. Martinez, Dirkje S. Postma, Stephen Rennard, Thys van der Molen, Asparuh Gardev, Eduardo Genofre, Peter Calverley Tags: Original Article Source Type: research

Omalizumab in allergic and non-allergic patients: results of FENOMA study
Conclusions: After 1 year with OMA, a comparable efficacy was showed between groups in reduction of: exacerbation rates, unscheduled PC/SC visits, RM and FEV1 improvement
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mardones Charroalde, A., Campo Mozo, P., Soto Campos, J. G., Moreira Jorge, A., Davila Gonzalez, I. J. Tags: Allergy and immunology Source Type: research

The effect of specific Hymenoptera VIT using the ultra-rush method on immunoregulatory properties of T and B Lymphocytes, histamine, tryptase and serum cytokine concentrations
Conclusions: Preliminary test results suggest that VIT has immunoregulatory properties influencing G-CSF, TGF-beta2 concentration, and CD3+ CD4+ helper T cells percentage.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Szymanski, L., Zakrzewski, A., Ciepielak, M., Cios, A., Urbanska, W., Kruszewski, J., Stankiewicz, W., Chciałowski, A. Tags: Allergy and immunology Source Type: research

Exploring the association between Socioeconomic status and asthma exacerbations: a real-world prospective cohort study in Chinese adults
Conclusions: In our observational study, we found that Chinese asthma patients with a low SES level had an increased risk for asthma-related hospital visits after adjustment for known clinical and environmental risk factors. Associations with systemic inflammation warrant further studies to explore underlying mechanisms.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Wang, G., Zhang, X., Zhang, L., Melen, E., Wang, L., Wang, G. Tags: Allergy and immunology Source Type: research

FDA Gives Guidance on Allergy, Pregnancy Concerns for COVID Vaccine FDA Gives Guidance on Allergy, Pregnancy Concerns for COVID Vaccine
Agency officials said Saturday the vaccine is safe for people with a history of any allergy, but not a history of severe reactions. Pregnancy concerns are less defined.Medscape Medical News
Source: Medscape Pulmonary Medicine Headlines - December 12, 2020 Category: Respiratory Medicine Tags: Infectious Diseases News Source Type: news

Association between Th2 biomarker levels and efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Many individuals with asthma have an underlying allergy, and house dust mites (HDMs) are a common trigger. Biomarkers of the type 2 (Th2) immune response are associated with severity of allergic asthma.The aim of this study was to investigate the association between baseline values of Th2 biomarkers and efficacy of sublingual allergy immunotherapy (SLIT)-tablet treatment.MITRA (Clinicaltrialsregister.eu 2010-018621-19) was a phase III, randomized, double-blind, placebo-controlled trial of HDM SLIT-tablets in 834 adults with HDM allergic asthma. A post-hoc analysis of the MITRA study population was performed to evaluate the...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Hoof, I., Witten, M., Stranzl, T., Brand, S., Shamji, M. H., Bateman, E. D., Bleecker, E. R., Andersen, P. S. Tags: Airway pharmacology and treatment Source Type: research

Impact of asthma-associated genetic polymorphisms on the efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma
Allergy to house dust mites (HDM) is a common cause of allergic asthma and can be effectively treated with allergy immunotherapy (AIT). Specific single-nucleotide polymorphisms (SNPs) have been associated with asthma, and specifically for the 17q12-21 locus, this association has been shown to be modifiable by environmental factors.The aim of this study was to test whether asthma-associated SNPs have an impact on the response to AIT.MITRA (Clinicaltrialsregister.eu 2010-018621-19) was a phase III, randomized, double-blind, placebo-controlled trial of HDM sublingual immunotherapy (SLIT)-tablets in adults with HDM allergic as...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Hoof, I., Bonnelykke, K., Witten, M., Stranzl, T., Li, X., Meyers, D. A., Bleecker, E. R., Andersen, P. S. Tags: Airway pharmacology and treatment Source Type: research

Identification of two distinct microbial enterophenotypes in children with moderate-to-severe asthma: results from the SysPharmPediA study
Conclusion: In our study of children with moderate-to-severe asthma, two distinct enterophenotypes correlating with clinical characteristics are present. Further research should assess if signatures in the gut microbiome could become a suitable precision medicine approach for diagnostics and treatment of asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Abdel-Aziz, M. I., Neerincx, A. H., Vijverberg, S. J. H., Hashimoto, S., Gorenjak, M., Toncheva, A. A., Kheiroddin, P., Harner, S., Brandstetter, S., Wolff, C., Sardon Prado, O., Elosegui, P. C., Murua, J. K., Pino-Yanes, M., Potocnik, U., Kabesch, M., Kr Tags: Paediatric asthma and allergy Source Type: research

Transcriptomic profiles of eosinophilic asthmatic patients classified according to their atopic status
Conclusions: : These results provide a preliminary overview of systemic changes in atopic versus non-atopic eosinophilic asthma and identify a range of interesting genes and pathways to investigate while building a consistant and representative cohort.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Gerday, S., Schleich, F., Guissard, F., Henket, M., Paulus, V., Louis, R. Tags: Allergy and immunology Source Type: research

Lack of Asthma Control More Likely With COVID - 19 - Related Anxiety
Second study shows most parents of children with food allergy report unchanged or decreased food allergy - specific anxiety during pandemic
Source: Pulmonary Medicine News - Doctors Lounge - October 12, 2017 Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Allergy, Pediatrics, Psychiatry, Pulmonology, Journal, Source Type: news

Allergy to Der p 23 influences the cytokine profile in patients with allergic asthma - a preliminary study
CONCLUSION: The higher Il-1 and Il-5 activities observed in profiles B and C with Der p 23 (+) could be responsible for the more effective acceleration of allergic inflammation than in profile A with Der p 23.PMID:35645174 | DOI:10.1080/02770903.2022.2083635
Source: Journal of Asthma - June 1, 2022 Category: Respiratory Medicine Authors: Andrzej Bo żek Jolanta Zalejska Fiolka Zenon Czuba Martyna Miodo ńska Renata Koz łowska Source Type: research

Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report
This report presents the proceedings from a workshop titled "Microbiome, Metabolism and Immunoregulation of Asthma" that was held virtually May 13 and 14, 2021. The workshop was jointly sponsored by the American Thoracic Society (Assembly on Allergy, Immunology, and Inflammation) and the National Institute of Allergy and Infectious Diseases. It convened an interdisciplinary group of experts with backgrounds in asthma immunology, microbiome science, metabolomics, computational biology, and translational pulmonary research. The main purpose was to identify key scientific gaps and needs to further advance research on microbia...
Source: Am J Respir Cell Mol... - August 1, 2022 Category: Respiratory Medicine Authors: Ariangela J Kozik Fernando Holguin Leopoldo N Segal Talal A Chatila Anne E Dixon James E Gern Catherine Lozupone Nicholas Lukacs Carey Lumeng Philip L Molyneaux Nichole Reisdorph Ivan Vujkovic-Cvijin Alkis Togias Yvonne J Huang Source Type: research