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Upregulation of NF‐κB activity mediates CYP24 expression and ROS production in indoxyl sulfate‐induced chronic kidney disease
ConclusionsThese results provide evidence that administration of IS in human renal tubular epithelial cells upregulates NF‐κB, which leads to increase CYP24 expression and ROS production. They also suggest that suppressing NF‐κB signaling is promising for the development into a strategy for CKD treatment.
Source: Nephrology - November 15, 2015 Category: Urology & Nephrology Authors: Lihua Wang, Zhiying Gao, Lili Wang, Yongning Gao Tags: Original Article Source Type: research

Upregulation of nuclear factor ‐κB activity mediates CYP24 expression and reactive oxygen species production in indoxyl sulfate‐induced chronic kidney disease
ConclusionsThese results provide evidence that administration of IS in human renal tubular epithelial cells upregulates NF‐κB, which leads to increase CYP24 expression and ROS production. They also suggest that suppressing NF‐κB signalling is promising for the development into a strategy for CKD treatment.
Source: Nephrology - August 21, 2016 Category: Urology & Nephrology Authors: Lihua Wang, Zhiying Gao, Lili Wang, Yongning Gao Tags: Original Article Source Type: research

Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research

Vitamin D/vitamin D receptor/Atg16L1  axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research

Vitamin D Receptor/Vitamin D Response Element Directly Modulate < b > < i > Nestin < /i > < /b > Transcription to Ameliorate PAN-Induced Podocyte Morphological Changes
Conclusions: Paricalcitol directly regulates nestin transcription through the interaction of VDR/VDRE, thereby preventing morphological changes of podocytes in PAN nephropathy.Nephron
Source: Nephron - May 6, 2022 Category: Urology & Nephrology Source Type: research