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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Human β-defensins are correlated with the immune infiltration and regulated by vitamin D < sub > 3 < /sub > in periodontitis
CONCLUSION: HBDs are correlated with immune infiltration in periodontitis. Vitamin D3 inhibits the expression of HBDs and chemokines induced by TNF-α/Pg-LPS, possibly through NF-κB pathway, in human gingival fibroblasts.PMID:37439265 | DOI:10.1111/jre.13159
Source: Cell Research - July 13, 2023 Category: Cytology Authors: Churen Zhang Ye Han Lili Miao Zhaoguo Yue Min Xu Kaining Liu Jianxia Hou Source Type: research
CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma
Arch Biochem Biophys. 2023 Jul 25:109701. doi: 10.1016/j.abb.2023.109701. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved in the metabolism of xenobiotics and procarcinogens. The present study was designed to investigate the potential role of CYP2E1 triggered endoplasmic reticulum stress in the progression of HCC through inhibition of apoptosis. In vitro CYP2E1 promotes HepG2 cell migration, reduced chromatin condensation, enhanced intracellular ROS accumulation and induce cell cycle progressio...
Source: Archives of Biochemistry and Biophysics - July 27, 2023 Category: Biochemistry Authors: Sharmeen Ishteyaque Karan Singh Yadav Smriti Verma Kaveri R Washimkar Madhav Nilakanth Mugale Source Type: research
Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain
AbstractThe cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases. CYP26A1, a member of the CYP450 family, carries out the oxidative metabolism of retinoic acid (RA), the active metabolite of vitamin A. Here we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation (SNL). CYP26A1 was mainly expressed in spinal neurons and astrocytes. HPLC analysis displayed that the content of all-trans-RA (at-RA), the substrate of CYP26A1, was reduced in the spinal cord on day 7 after SNL. Inhibition of ...
Source: Neuroscience Bulletin - August 28, 2023 Category: Neuroscience Source Type: research
