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Nutrition: Zinc
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Total 1207 results found since Jan 2013.
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
Perspectives of circular RNAs in diabetic complications from biological markers to potential therapeutic targets (Review)
Mol Med Rep. 2023 Oct;28(4):194. doi: 10.3892/mmr.2023.13081. Epub 2023 Sep 8.ABSTRACTChronic complications of diabetes increase mortality and disability of patients. It is crucial to find potential early biomarkers and provide novel therapeutic strategies for diabetic complications. Circular RNAs (circRNAs), covalently closed RNA molecules in eukaryotes, have high stability. Recent studies have confirmed that differentially expressed circRNAs have a vital role in diabetic complications. Certain circRNAs, such as circRNA ankyrin repeat domain 36, circRNA homeodomain‑interacting protein kinase 3 (circHIPK3) and circRNA WD...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Lingling Yuan Jinsheng Duan Hong Zhou Source Type: research
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease
J Cell Mol Med. 2023 Sep 5. doi: 10.1111/jcmm.17946. Online ahead of print.ABSTRACTParkinson's disease (PD) is a challenge because of the ageing of the population and the disease's complicated pathogenesis. Accumulating evidence showed that iron and autophagy were involved in PD. Nevertheless, the molecular mechanism and role of iron and autophagy in PD are not yet elucidated. In the present study, it was shown that PD mice had significant motor dysfunction, increased iron content, less dopamine neurons and more α-synuclein accumulation in the substantia nigra. Meanwhile, PD mice treated with deferoxamine exhibited less i...
Source: J Cell Mol Med - September 5, 2023 Category: Molecular Biology Authors: Yinying Wang Qian Wen Rongsha Chen Zhichao Gan Xinwei Huang Pengfei Wang Xia Cao Ninghui Zhao Zhongshan Yang Jinyuan Yan Source Type: research
A novel loss of function mutation in the PHD domain of the RAG2 gene, affecting zinc-binding affinity
CONCLUSION: The identification of a novel pathogenic variant, c.1268G > C, revealed that this variant in the zinc-binding domain diminished the affinity of the zinc ion to the mutant protein and consequently led to the loss of its ability to bind to the RSS.PMID:37573280 | DOI:10.1007/s11033-023-08731-8
Source: Mol Biol Cell - August 12, 2023 Category: Molecular Biology Authors: Neda Jabbarpour Mortaza Bonyadi Leila Sadeghi Source Type: research
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
J Cell Mol Med. 2023 Aug 8. doi: 10.1111/jcmm.17900. Online ahead of print.ABSTRACTFinding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non-small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Canc...
Source: J Cell Mol Med - August 8, 2023 Category: Molecular Biology Authors: Fujie Shi Yunfei Wu Kai Wang Jiafan Wang Minghui Liu Xinlei Sun Source Type: research
Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
In this study, we found that CXXC-type zinc finger protein 5 (CXXC5), a negative regulator of the Wnt/β-catenin pathway, was overexpressed with suppression of the Wnt/β-catenin pathway and its target genes involved in wound healing and angiogenesis in the wound tissues of DFU patients and diabetes-induced model mice. KY19334, a small molecule that activates the Wnt/β-catenin pathway by inhibiting the CXXC5-Dvl interaction, accelerated wound healing in diabetic mice. The enhancement of diabetic wound healing could be achieved by restoring the suppressed Wnt/β-catenin signaling and subsequently inducing its target genes....
Source: Molecular Medicine - July 31, 2023 Category: Molecular Biology Authors: Eunhwan Kim Seol Hwa Seo Yumi Hwang Yeong Chan Ryu Heejene Kim Kyoung-Mi Lee Jin Woo Lee Kwang Hwan Park Kang-Yell Choi Source Type: research
SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways
Exp Mol Med. 2023 Aug 1. doi: 10.1038/s12276-023-01062-5. Online ahead of print.ABSTRACTSolute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters and plays a key role in B-cell development. Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn2+); however, its role in gastric cancer remains totally unclear. Here, we found that SLC39A10 expression was frequently increased in gastric adenocarcinomas and that SLC39A10 upregulation was strongly associated with poor patient outcomes; in addition, we identified SLC39A10 as a...
Source: Molecular Medicine - July 31, 2023 Category: Molecular Biology Authors: Xiaojuan Ren Chao Feng Yubo Wang Pu Chen Simeng Wang Jianling Wang Hongxin Cao Yujun Li Meiju Ji Peng Hou Source Type: research
