Filtered By:
Specialty: Toxicology
Nutrition: Vitamin A

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 864 results found since Jan 2013.

Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung.
Abstract β-Carotene (BC) is omnipresent in our diet, both as natural food component as well as an additive. BC and its metabolites have important biological functions. For this reason, BC is generally considered to be a health promoting compound. Two human trials, however, have described adverse effects in lung tissue, increasing the risk of lung cancer. We previously applied transcriptomic analyses in a unique animal model, beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1(-/-)) mice that are, like humans, able to accumulate intact BC. In our search to unravel the molecular action of BC in the lung, we previo...
Source: Toxicology - March 21, 2014 Category: Toxicology Authors: Piga R, van Dartel D, Bunschoten A, van der Stelt I, Keijer J Tags: Toxicology Source Type: research

A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas).
Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 genome editing allows for the disruption or modification of genes in a multitude of model organisms. In the present study, we describe and employ the method for use in the fathead minnow (Pimephales promelas), in part, to assist in the development and validation of adverse outcome pathways (AOPs). The gene coding for an enzyme responsible for melanin production, tyrosinase (tyr), was the initial target chosen for development and assessment of the method since its disruption results in abnormal pigmentation, a phenotype obvious within ...
Source: Aquatic Toxicology - March 1, 2020 Category: Toxicology Authors: Maki JA, Cavallin JE, Lott KG, Saari TW, Ankley GT, Villeneuve DL Tags: Aquat Toxicol Source Type: research

Comparison of the Short-term Effect of Aflibercept and Dexamethasone Implant on Serous Retinal Detachment in the Treatment of Naive Diabetic Macular Edema.
Conclusions: Fewer injections of dexamethasone implant demonstrated better morphological results than aflibercept in the early treatment period of naive diabetic macular edema (DME) with serous retinal detachment (SRD). PMID: 31438736 [PubMed - as supplied by publisher]
Source: Cutaneous and Ocular Toxicology - August 22, 2019 Category: Toxicology Authors: Bolukbasi S, Cakir A, Erden B, Karaca G Tags: Cutan Ocul Toxicol Source Type: research

beta-carotene: friend or foe?
Fundam Appl Toxicol. 1997 Dec;40(2):163-74. doi: 10.1006/faat.1997.2387.ABSTRACTThis symposium focused on the research which documents benefit and toxicity in beta-carotene supplementation. Reflecting on past and current studies, the panel of experts discussed: (1) the potential harm of a high intake of beta-carotene on selected populations, (2) biochemical antioxidant/prooxidant mechanisms of beta-carotene at the cellular level, (3) potential benefits of other carotenoids and antioxidants, and (4) future directions for research in beta-carotene and other antioxidants.PMID:9441712 | DOI:10.1006/faat.1997.2387
Source: Fundamental and Applied Toxicology - January 27, 1998 Category: Toxicology Authors: S T Omaye N I Krinsky V E Kagan S T Mayne D C Liebler W R Bidlack Source Type: research

Single-dose and chronic dietary neurotoxicity screening studies on 2,4-dichlorophenoxyacetic acid in rats
Fundam Appl Toxicol. 1997 Nov;40(1):111-9. doi: 10.1006/faat.1997.2361.ABSTRACTForms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Single-dose acute and 1-year chronic neurotoxicity screening studies in male and female Fischer 344 rats (10/sex/dose) were conducted on 2,4-D according to the U.S. EPA 1991 guidelines. The studies emphasized a Functional Observational Battery (which included grip performance and hindlimb splay tests), automated motor activity testing, and comprehensive neurohistopathology of perfused tissues. Dosages...
Source: Fundamental and Applied Toxicology - December 17, 1997 Category: Toxicology Authors: J L Mattsson J M Charles B L Yano H C Cunny R D Wilson J S Bus Source Type: research

beta-carotene: friend or foe?
Fundam Appl Toxicol. 1997 Dec;40(2):163-74. doi: 10.1006/faat.1997.2387.ABSTRACTThis symposium focused on the research which documents benefit and toxicity in beta-carotene supplementation. Reflecting on past and current studies, the panel of experts discussed: (1) the potential harm of a high intake of beta-carotene on selected populations, (2) biochemical antioxidant/prooxidant mechanisms of beta-carotene at the cellular level, (3) potential benefits of other carotenoids and antioxidants, and (4) future directions for research in beta-carotene and other antioxidants.PMID:9441712 | DOI:10.1006/faat.1997.2387
Source: Fundamental and Applied Toxicology - January 27, 1998 Category: Toxicology Authors: S T Omaye N I Krinsky V E Kagan S T Mayne D C Liebler W R Bidlack Source Type: research