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Specialty: Opthalmology
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Total 40 results found since Jan 2013.

Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles.
Abstract In this paper, the effect of surface charge of intravitreal lipid nanoparticles (LNPs) on their intraocular accumulation and distribution was quantitatively and systematically studied. The retinal distribution of LNPs delivering model drug (siRNA) with optimal surface charge was visualized as well. LNPs and siRNA-loaded LNPs (siLNPs) were prepared with ethanol-injection method. C57BL/6 Mice with the age of 6-8 weeks were used for the animal experiments. Quantitative accumulation in the eye and respective intraocular distribution of the intravitreally injected LNPs with different surface charge were examin...
Source: Experimental Eye Research - June 21, 2019 Category: Opthalmology Authors: Huang X, Chau Y Tags: Exp Eye Res Source Type: research

Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-{beta}/{delta} Retinal Cell Biology
Conclusions. These data suggest a protective effect for PPARβ/ antagonism against VEGF-induced vascular permeability, possibly through reduced VEGFR expression. Therefore, antagonism/reverse agonism of PPARβ/ siRNA may represent a novel therapeutic methodology against retinal hyperpermeability and is worthy of future investigation.
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Suarez, S., McCollum, G. W., Bretz, C. A., Yang, R., Capozzi, M. E., Penn, J. S. Tags: Retinal Cell Biology Source Type: research

Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research

Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells
CONCLUSIONS: C3 was elevated in RPE under environmental stimulus and long-term exposure to specified concentration of C3a increased CCN2/CTGF expression in RPE, which could be partially reversed by C3 siRNA.PMID:36276919 | PMC:PMC9581697 | DOI:10.1155/2022/3259453
Source: Journal of Ophthalmology - October 24, 2022 Category: Opthalmology Authors: Kang Xiao Zhiyan Xu Zhengyu Chen Qin Long Youxin Chen Source Type: research

Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Experimental Eye Research - November 26, 2022 Category: Opthalmology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research

Heparanase-mediated histone 3 acetylation regulates VEGF gene transcription in the hyperglycemia and hypoxia human retinal endothelial cells
Exp Eye Res. 2023 Jun 3:109519. doi: 10.1016/j.exer.2023.109519. Online ahead of print.ABSTRACTHeparanase (HPA) is believed that might mediate histone 3 lysine 9 acetylation (H3K9ac) to regulate vascular endothelial growth factor (VEGF) gene expressions in the hyperglycemia and hypoxia human retinal endothelial cells (HRECs). Cultured human retinal endothelial cells (HRECs) in hyperglycemia, hypoxia, siRNA, and normal medium, respectively. Distributions of H3K9ac and HPA in HRECs were analyzed by immunofluorescence. Western blot and real-time PCR were respectively used to evaluate the expression of HPA, H3K9ac, and VEGF. T...
Source: Experimental Eye Research - June 5, 2023 Category: Opthalmology Authors: Xuan Leng Jingwei Wang Xin Song Jie Hu Lin Lu Source Type: research