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Lycium barbarum polysaccharide-glycoprotein ameliorates ionizing radiation-induced epithelial injury by regulating oxidative stress and ferroptosis via the Nrf2 pathway
In conclusion, we demonstrated that LBP attenuates ionizing radiation-induced oral mucosa injury by reducing oxidative stress and inhibiting ferroptosis via the Nrf2 signaling pathway. LBP may be a promising medical countermeasure against RIOM.PMID:37119863 | DOI:10.1016/j.freeradbiomed.2023.04.020
Source: Free Radical Biology and Medicine - April 29, 2023 Category: Biology Authors: Si-Jing Jiang Xun Xiao Jing Li Yangdong Mu Source Type: research

Phytoradiotherapy to enhance cancer treatment outcomes with cannabidiol, bitter melon juice, and plant hemoglobin
In this study, a protocol for testing the radiosensitizing effects of phytomedicines was validated and used to investigate the well-known plant based medicine cannabidiol (CBD) and the lesser-known medicinal fruit Bitter Melon. Additionally, based on its high concentration of plant hemoglobin which has been shown to abate hypoxia, the African-indigenous Justicia plant was tested in pancreatic adenocarcinoma mouse models. The studies reveal that these phytomedicines can effectively enhance tumor cell killing, minimize tumor growth, and prolong mice survival. There is certainly the need for additional research in this regard...
Source: Cancer Control - February 13, 2023 Category: Cancer & Oncology Authors: Tyler Alfonzetti Michele Moreau Sayeda Yasmin-Karim Wilfred Ngwa Stephen Avery Denisa Goia Source Type: research

Review on Natural Bioactive Products as Radioprotective Therapeutics :Present & amp; Past Perspective
We present the merits and demerits of radiation therapy; cell stress generation of reactive oxygen species (ROS) associated with radiation need and availability of radio-protectors. Finally, we discuss green-based bioactive compounds which have radioprotective properties.PMID:35016594 | DOI:10.2174/1389201023666220110104645
Source: Current Pharmaceutical Biotechnology - January 12, 2022 Category: Biotechnology Authors: Seema Raj Romila Manchanda Meena Bhandari Md Sabir Alam Source Type: research