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Total 594 results found since Jan 2013.
Modulating Plaque Inflammation < em > via < /em > Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis
ACS Nano. 2023 Sep 5. doi: 10.1021/acsnano.3c00958. Online ahead of print.ABSTRACTAtherosclerosis is a common pathology present in many cardiovascular diseases. Although the current therapies (including statins and inhibitors of the serine protease PCSK9) can effectively reduce low-density lipoprotein (LDL) cholesterol levels to guideline-recommended levels, major adverse cardiovascular events still occur frequently. Indeed, the subendothelial retention of lipoproteins in the artery wall triggers multiple events of inflammation in macrophages and is a major contributor to the pathological progression of atherosclerosis. It...
Source: Atherosclerosis - September 5, 2023 Category: Cardiology Authors: Mingzhu Gao Maoping Tang William Ho Yilong Teng Qijing Chen Lei Bu Xiaoyang Xu Xue-Qing Zhang Source Type: research
Effects and mechanism of Kedaling tablets for atherosclerosis treatment based on network pharmacology, molecular docking and experimental study
CONCLUSIONS: KDL attenuated AS in ApoE-/- mice, which was associated with a suppression of inflammatory signalling through the TNF and TGF-β pathways.PMID:37657772 | DOI:10.1016/j.jep.2023.117108
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Hongzheng Li Wenwen Yang Weiyi Cao Zikai Yu Guoyuan Zhang Linzi Long Hao Guo Hua Qu Changgeng Fu Keji Chen Source Type: research
Silent Myocardial Infarction: A Case Report
We present a case of a 59-year-old overweight woman with prediabetes, primary hypertension, and hypercholesterolemia who presented for herpes zoster (HZ) follow-up; she reported having skipped heartbeats and heart rate fluctuations during the review of systems. On further workup, ECG revealed low voltage QRS complexes, flat QRS complexes, flat T waves, and pathological Q waves, suggesting the diagnosis of SMI. Based on the identified risk factors, including high BMI, prediabetes, primary hypertension, hypercholesterolemia, HZ, and newly diagnosed SMI, the patient was advised to continue with lisinopril 20 mg daily, prescri...
Source: Herpes - August 28, 2023 Category: Infectious Diseases Authors: Maria V Kolesova Suzanne Minor Source Type: research
Using stable carbon isotope ratio analysis to detect adulteration in red yeast rice dietary supplements
Talanta. 2023 Aug 23;266(Pt 2):125076. doi: 10.1016/j.talanta.2023.125076. Online ahead of print.ABSTRACTRed yeast rice (RYR) is marketed as a dietary supplement because it contains natural 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), including monacolin K. However, there is concern that some RYR supplements may be adulterated with the pharmaceutical drug lovastatin to enhance health claims. We have developed an optimized method to isolate monacolin K/lovastatin from complex RYR dietary supplement matrices to then test for adulteration in RYR supplements using stable carbon isotope (δ13C) analysis...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Kristen M Hannon Joshua D Sabala Madhavi Mantha Lisa M Lorenz John P Roetting Ii Matteo Perini Silvia Pianezze Kevin M Kubachka Source Type: research
Hypercholesterolemia - who, when, how to treat?
Dtsch Med Wochenschr. 2023 Sep;148(17):1088-1094. doi: 10.1055/a-1956-9851. Epub 2023 Aug 23.ABSTRACTIn recent years, clinical scientific data on LDL cholesterol and atherosclerosis has led to lowering of LDL-C targets and the expansion of the indication for lipid drug therapy to larger populations or patients. The calculators SCORE2 and SCORE-OP were newly developed to calculate the cardiovascular risk in primary prevention. When assessing the cardiovascular risk of patients, in addition to e.g., pre-existing cardiovascular disease, familial hypercholesterolaemia and type II diabetes, type I diabetes, diabetic complicatio...
Source: Atherosclerosis - August 23, 2023 Category: Cardiology Authors: Martin Merkel Source Type: research
The role of cepharanthine as an anti-atherosclerotic agent in rats
Pak J Pharm Sci. 2023 Jul;36(4):1073-1077.ABSTRACTThis investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established: a high-fat high sucrose diet (HFHS), HFHS supplemented with intraperitoneal cepharanthine (HFHS-C) or oral atorvastatin (HFHS-A) from the 8th week, and a normal-fat diet (NFD). The study aimed to evaluate diet and drug impact on aortic histopathological changes over 16 weeks. Our results revealed significant atherosclerosis...
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: - Adnan Iqbal - Rahila Najam - Saira Saeed Khan - Sumera Imran - Muhammad Osama - Anosh Tahir - Muhammad Imran - Bilal Jawed - Zeeshan Ahmed - Azfar Athar Ishaqui Source Type: research
Clinical Approach in the Management of Paediatric Patients with Familial Hypercholesterolemia: A National Survey Conducted by the LIPIGEN Paediatric Group
Nutrients. 2023 Aug 5;15(15):3468. doi: 10.3390/nu15153468.ABSTRACTDetection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is fundamental to reduce morbidity and mortality. The activity of National realities such as the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) Paediatric Group, founded in 2018, is a milestone in this context. The aim of this exploratory survey, conducted in October 2021 among Italian lipid clinics included in the LIPIGEN Paediatric Group, was to investigate the current clinical approach in the management and treatment of paediatric patients wit...
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Cristina Pederiva Marta Gazzotti Marcello Arca Maurizio Averna Giuseppe Banderali Giacomo Biasucci Marta Brambilla Paola Sabrina Buonuomo Paolo Calabr ò Francesco Cipollone Nadia Citroni Sergio D'Addato Maria Del Ben Simonetta Genovesi Ornella Guardamagn Source Type: research
Xinmaikang-mediated mitophagy attenuates atherosclerosis via the PINK1/Parkin signaling pathway
CONCLUSION: The study shows that XMK is effective against AS by mediating macrophage mitophagy via the PINK1/Parkin signaling pathway. For the treatment of AS and drug discovery, it provides an experimental basis and target.PMID:37572567 | DOI:10.1016/j.phymed.2023.154955
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Yanhong Cao Xin Chen Fuqiang Pan Mingyang Wang Haowen Zhuang Jiangna Chen Lu Lu Lingjun Wang Ting Wang Source Type: research
Clinical Approach in the Management of Paediatric Patients with Familial Hypercholesterolemia: A National Survey Conducted by the LIPIGEN Paediatric Group
Nutrients. 2023 Aug 5;15(15):3468. doi: 10.3390/nu15153468.ABSTRACTDetection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is fundamental to reduce morbidity and mortality. The activity of National realities such as the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) Paediatric Group, founded in 2018, is a milestone in this context. The aim of this exploratory survey, conducted in October 2021 among Italian lipid clinics included in the LIPIGEN Paediatric Group, was to investigate the current clinical approach in the management and treatment of paediatric patients wit...
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Cristina Pederiva Marta Gazzotti Marcello Arca Maurizio Averna Giuseppe Banderali Giacomo Biasucci Marta Brambilla Paola Sabrina Buonuomo Paolo Calabr ò Francesco Cipollone Nadia Citroni Sergio D'Addato Maria Del Ben Simonetta Genovesi Ornella Guardamagn Source Type: research
Association between telomere length and intima-media thickness of both common carotid arteries in patients with coronary heart disease: From the CORDIOPREV randomized controlled trial
CONCLUSIONS: Patients who had a reduced TL exhibited a greater decrease in IMT-CC after consuming a Mediterranean diet.PMID:37549582 | DOI:10.1016/j.atherosclerosis.2023.117193
Source: Atherosclerosis - August 7, 2023 Category: Cardiology Authors: Ana Ojeda-Rodriguez Juan F Alcala-Diaz Oriol Alberto Rangel-Zu ñiga Antonio Pablo Arenas-de Larriva Francisco M Gutierrez-Mariscal Purificaci ón Gómez-Luna Jose D Torres-Pe ña Antonio Garcia-Rios Juan L Romero-Cabrera Maria M Malagon Pablo Perez-Marti Source Type: research
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: Atherosclerosis - August 3, 2023 Category: Cardiology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research
