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Nutrition: Calcium
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Total 268 results found since Jan 2013.
Congenital myopathies
The sarcolemmal voltage-gated L-type Ca2+ channel (CaV1.1), also known as the dihydropyridine receptor (DHPR), is encoded by CACNA1S and localized in the T-tubule. During skeletal muscle excitation-contraction coupling (ECC), CaV1.1 activated by membrane depolarizations triggers opening of the sarcoplasmic Ca2+ release channel (RyR1) to release Ca2+ for myofibril contraction. Recently, both recessive and dominant CACNA1S mutations are identified as a cause of a novel congenital myopathy with alternations in calcium homeostasis and impaired ECC.
Source: Neuromuscular Disorders - September 19, 2021 Category: Neurology Authors: Y. Endo, E. Pannia, S. Wang, L. Groom, R. Dirksen, J. Dowling Source Type: research
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat-high sucrose-feeding
Can J Physiol Pharmacol. 2021 Oct 25. doi: 10.1139/cjpp-2021-0587. Online ahead of print.ABSTRACTSarco(endo)plasmic reticulum calcium (Ca2+) ATPase (SERCA) transports Ca2+ in muscle. Impaired SERCA activity contributes to diabetic myopathy. Sirtuin (SIRT) 3 regulates muscle metabolism and function. However, it is unknown if SIRT3 regulates muscle SERCA activity. We determined if SIRT3 overexpression enhances SERCA activity in mouse gastrocnemius muscle and if SIRT3 overexpression preserves gastrocnemius SERCA activity in a model of type 2 diabetes, induced by high fat-high sucrose (HFHS)-feeding. We also determined if the ...
Source: Canadian Journal of Physiology and Pharmacology - October 25, 2021 Category: Drugs & Pharmacology Authors: Christopher Oldfield Teri L Moffatt Vernon W Dolinsky Todd A Duhamel Source Type: research
Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations
This study supports the utility of patient-specific iPSC experimental platform in the exploration of mechanistic and phenotypic heterogeneity of different mutations within a cardiac disease-associated gene. The addition of genetically defined coculture of cardiac-constituent non-myocytes further expands the capabilities of this approach.
Source: Frontiers in Physiology - December 16, 2021 Category: Physiology Source Type: research
The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ
Biochem Biophys Res Commun. 2021 Dec 17;588:29-33. doi: 10.1016/j.bbrc.2021.12.051. Online ahead of print.ABSTRACTThe molecular mechanisms of pathogenesis of atrial myopathy associated with hypertrophic (HCM) and dilated (DCM) mutations of sarcomeric proteins are still poorly understood. For this, one needs to investigate the effects of the mutations on actin-myosin interaction in the atria separately from ventricles. We compared the impact of the HCM and DCM mutations of tropomyosin (Tpm) on the calcium regulation of the thin filament interaction with atrial and ventricular myosin using an in vitro motility assay. We foun...
Source: Biochemical and Biophysical Research communications - December 23, 2021 Category: Biochemistry Authors: Galina V Kopylova Valentina Y Berg Anastasia M Kochurova Alexander M Matyushenko Sergey Y Bershitsky Daniil V Shchepkin Source Type: research
