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Researchers to Study Why COVID-19 Strikes Asthma Sufferers Less Severely Than Others
A University of Arizona Health Sciences-led research team received $7.16 million in federal funding to study how to better control severe asthma and determine why sufferers are less likely to contract COVID-19, influenza and rhinovirus. Today University of Arizona Health Scienceswomen_blowing_nose-948301830-hero-web.jpgHealthCollege of Medicine - TucsonExpertsExplorationResearchAn investigation into why asthma sufferers are less likely to contract COVID-19 is one of several aims for research funded through a $7.16 million National Institutes of Health cooperative agreement with the  Asthma and Airway Disease Research ...
Source: The University of Arizona: Health - December 9, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients
This study was approved by our local ethical review committee in compliance with the declaration of Helsinki. Informed and written consent was obtained from all patients (Ethic Committee Charité University Medicine, Berlin, Germany, EA2/028/13). The study cohort consisted of 7 kidney transplant recipients with sustained BKV reactivation (Table 1). The HLA typing for each patient and donor is summarized in Figure 1. TABLE 1 Table 1. Characteristics of patients with BKV reactivation. FIGURE 1 Figure 1. Recipient and donor HLA type. HLA type of the patients and their kidney donors. Black square i...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research