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Infectious Disease: Herpes

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Total 364 results found since Jan 2013.

Encephalitis in Australian children: contemporary trends in hospitalisation
Conclusion Hospitalisation of childhood encephalitis has slightly decreased in Australia. High rates of childhood immunisation have been associated with a reduction of varicella-associated encephalitis in Australian children. ADEM, an immune-mediated encephalitis, is the most common recognised cause of encephalitis in children. Young children (<1 year) have the highest admission rates. The high proportion of ‘unspecified’ encephalitis deaths and hospitalisations is an ongoing challenge.
Source: Archives of Disease in Childhood - December 14, 2015 Category: Pediatrics Authors: Britton, P. N., Khoury, L., Booy, R., Wood, N., Jones, C. A. Tags: Health policy, Immunology (including allergy), Meningitis, Vaccination / immunisation, Infection (neurology), Health economics, Health service research Original article Source Type: research

Second dose of herpes zoster vaccine beneficial to seniors
The herpes zoster vaccine should be administered earlier rather than later in order to achieve optimal immune response, but an additional booster shot for individuals 70 years or older is also advisable. This is according to a recent study published in the Journal of Infectious Diseases, which...
Source: Skin and Allergy News - December 19, 2015 Category: Dermatology Source Type: news

Asthma as a risk factor for zoster in adults: A population-based case-control study
We recently reported an increased risk of herpes zoster (shingles or zoster) in children with asthma, but little is known about whether the same is true for adults with asthma.
Source: Journal of Allergy and Clinical Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Hyo Jin Kwon, Duk Won Bang, Eun Na Kim, Chung-Il Wi, Barbara P. Yawn, Peter C. Wollan, Brian D. Lahr, Euijung Ryu, Young J. Juhn Source Type: research

GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus–associated hemophagocytic lymphohistiocytosis
We describe an 18-year-old woman with lymphedema who developed severe blastomycosis and fatal hemophagocytic lymphohistiocytosis (HLH) associated with disseminated herpes simplex virus-1 (HSV-1) infection.
Source: Journal of Allergy and Clinical Immunology - September 19, 2015 Category: Allergy & Immunology Authors: Michael A. Spinner, Jennifer P. Ker, Charles J. Stoudenmire, Oluwole Fadare, Emily M. Mace, Jordan S. Orange, Amy P. Hsu, Steven M. Holland Tags: Letter to the Editor Source Type: research

The Latest On Zika: Infection In Utero May Trigger Mental Illness
The Zika virus, which is spread by the Aedes aegypti mosquito, is strongly suspected to be linked to a new wave of microcephaly cases in Brazil. Babies born with the birth defect have smaller heads and sometimes brains that aren't fully developed, which can result in life-long developmental problems.    Zika is currently spreading through Central and South America and the Caribbean, and with the high volume of news about the virus, it's tough to stay up-to-date. Check out our full coverage, or read our daily recaps. Here are seven updates, opinions and developments to know about now:   1. Conf...
Source: Healthy Living - The Huffington Post - February 22, 2016 Category: Consumer Health News Source Type: news

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy
Herpes viruses such as herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella zoster virus cause vesicular lesions of the oral mucosa and skin, but can also affect other organs.1 After acute infection, the virus resides in a latent state and reactivates when the host immune response is impaired. Although most herpes infections are self-limiting, immunosuppression predisposes to reactivation and severity.2 Reactivations of herpes virus infections have been reported in patients with primary immunodeficiencies, and these studies demonstrated that innate pattern recognition is crucial for protection.
Source: Journal of Allergy and Clinical Immunology - April 5, 2016 Category: Allergy & Immunology Authors: Peer Arts, Frank L. van de Veerdonk, Robin van der Lee, Martijn A. Langereis, Christian Gilissen, Wendy A.G. van Zelst-Stams, Martijn A. Huynen, Jos W.M. van der Meer, Frank J. van Kuppeveld, Joris A. Veltman, Bart Jan Kullberg, Alexander Hoischen, Mihai Tags: Letter to the Editor Source Type: research

Efficacy and safety of the oral Janus kinase inhibitor peficitinib (ASP015K) monotherapy in patients with moderate to severe rheumatoid arthritis in Japan: a 12-week, randomised, double-blind, placebo-controlled phase IIb study
Conclusions Treatment with peficitinib as monotherapy for 12 weeks in Japanese patients with moderate to severe RA is efficacious and showed acceptable safety profile. These findings support further developments of peficitinib for RA treatment. Trial registration number NCT01649999; Results.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Takeuchi, T., Tanaka, Y., Iwasaki, M., Ishikura, H., Saeki, S., Kaneko, Y. Tags: Open access, Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis
Conclusions Within the global tofacitinib RA development programme, TB was the most common OI reported but was rare in regions of low and medium TB incidence. Patients who screen positive for latent TB can be treated with isoniazid during tofacitinib therapy.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Winthrop, K. L., Park, S.-H., Gul, A., Cardiel, M. H., Gomez-Reino, J. J., Tanaka, Y., Kwok, K., Lukic, T., Mortensen, E., Ponce de Leon, D., Riese, R., Valdez, H. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Efficacy and safety of tofacitinib following inadequate response to conventional synthetic or biological disease-modifying antirheumatic drugs
Conclusions Tofacitinib demonstrated efficacy in both bDMARD-naive and bDMARD-IR patients with RA. Clinical response to tofacitinib was generally numerically greater in bDMARD-naive than bDMARD-IR patients. The safety profile appeared similar between subpopulations. Trial registration numbers (NCT00413660, NCT0050446, NCT00603512, NCT00687193, NCT00960440, NCT00847613, NCT00814307, NCT00856544, NCT00853385).
Source: Annals of the Rheumatic Diseases - June 9, 2016 Category: Rheumatology Authors: Charles-Schoeman, C., Burmester, G., Nash, P., Zerbini, C. A. F., Soma, K., Kwok, K., Hendrikx, T., Bananis, E., Fleischmann, R. Tags: Open access, Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Bacterial and Viral Infections in Atopic Dermatitis: a Comprehensive Review
Abstract Atopic dermatitis (AD) is the most common allergic skin disease in the general population. It is a chronic inflammatory skin disease complicated by recurrent bacterial and viral infections that, when left untreated, can lead to significant complications. The current article will review immunologic and molecular mechanisms underlying the propensity of AD patients to microbial infections. These infections include Staphylococcus aureus (S. aureus) skin infections, eczema herpeticum, eczema vaccinatum, and eczema coxsackium. Previous studies have shown that skin barrier defects, a decrease in antimicrobial pe...
Source: Clinical Reviews in Allergy and Immunology - July 4, 2016 Category: Allergy & Immunology Source Type: research

Decision Support in Medicine: Herpes Zoster
1. Are you confident of the diagnosis?What you should be alert for in the historyA history of prodrome with acute stinging, itching, burning, paresthesias, and hyperesthesia in a single dermatome is characteristic of herpes zoster. Patients may also complain of...
Source: Skin and Allergy News - July 5, 2016 Category: Dermatology Source Type: news

UAB research team awarded $11.5M contract
A group of researchers at the University of Alabama at Birmingham was recently awarded an $11.5 million contract to study treatment of babies born with congenital cytomegalovirus and frequency of neonatal herpes infections in the United States and Peru. The National Institute of Allergy and Infectious Disease awarded the funding to the UAB Department of Pediatrics to support two studies slated to be conducted at UAB and its partner academic sites. Nearly 1 percent of babies born in the United States…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 15, 2016 Category: Pharmaceuticals Authors: Tim Steere Source Type: news

Cd4 lymphocytopenia without hiv infection.
We report the case of a 82-year-old female who presented with a markedly low CD4 count during a severe lower respiratory tract infection and respiratory failure without HIV infection. The total lymphocyte and the absolute CD4 counts are 255/mm³ and 109/mm³, respectively. Sputum and bronchial lavage fluid were both negative for acid-fast bacilli. The anti-HIV antibody test was negative.The blood culture was also negative. She had no history of diabetes, malnutrition or chronic kidney disease. Because pneumocystis jiroveci pneumonia could not be excluded, she was treated with a combination of clindamycin, dexamethasone, pr...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - July 16, 2016 Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN- γ therapy
Herpes viruses such as herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella zoster virus cause vesicular lesions of the oral mucosa and skin, but can also affect other organs.1 After acute infection, the virus resides in a latent state and reactivates when the host immune response is impaired. Although most herpes infections are self-limiting, immunosuppression predisposes to reactivation and severity.2 Reactivations of herpes virus infections have been reported in patients with primary immunodeficiencies, and these studies demonstrated that innate pattern recognition is crucial for protection.
Source: Journal of Allergy and Clinical Immunology - April 5, 2016 Category: Allergy & Immunology Authors: Peer Arts, Frank L. van de Veerdonk, Robin van der Lee, Martijn A. Langereis, Christian Gilissen, Wendy A.G. van Zelst-Stams, Martijn A. Huynen, Jos W.M. van der Meer, Frank J. van Kuppeveld, Joris A. Veltman, Bart Jan Kullberg, Alexander Hoischen, Mihai Tags: Letter to the Editor Source Type: research