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Janssen Presents Results of First Head-to-Head Study of Biologic Therapies in Patients with Moderate to Severe Crohn ’s Disease
SPRING HOUSE, PENNSYLVANIA, May 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced efficacy and safety data for STELARA® (ustekinumab) in Crohn’s disease (CD) and ulcerative colitis (UC),1-4including data from the SEAVUE study, the first head-to-head study of biologic therapies in patients with CD, presented in a Clinical Science Late-Breaking Abstract Plenary session.1 SEAVUE data showed treatment with STELARA demonstrated high rates of clinical remission, corticosteroid-free remission, clinical response and endoscopic response through one year in biologic-naïve patients with mo...
Source: Johnson and Johnson - May 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Bilateral upper lobe Pneumocystis pneumonia during aerosolized pentamidine prophylaxis
A 37-year-old man with human immunodeficiency virus (HIV) infection presented to our hospital due to a 9-day history of fever, cough and dyspnea on exertion. He was diagnosed with HIV infection 6  years before the admission. However, combination antiretroviral therapy (cART) was only administered 9 days before admission because a previous physician could not obtain the patient’s consent. He was receiving aerosolized pentamidine, rather than trimethoprim-sulfamethoxazole, for 3 months as aPneumocystis prophylaxis because of his prior sulfa allergy. Clinical examinations revealed high-grade fever, tachycardia and res...
Source: QJM - December 1, 2017 Category: Internal Medicine Source Type: research

Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California
Conclusions: Residential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699 Received: 31 January 2017 Revised: 18 August 2017 Accepted: 23 August 2017 Published: 29 September 2017 Address correspondence to R.J. Blount, Divisions of Pulmonary and Critical Care Medicine and Pediatric Pulmon...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Dilemma of managing asymptomatic children referred with 'culture-confirmed drug-resistant tuberculosis
Conclusions Bacteriological evaluation should not be performed in the absence of any clinical indication. If drug-resistant Mycobacterium tuberculosis is detected in an asymptomatic child with a normal chest radiograph, close observation may be an appropriate strategy, especially in settings where potential laboratory error and poor record keeping are constant challenges.
Source: Archives of Disease in Childhood - June 16, 2016 Category: Pediatrics Authors: Loveday, M., Sunkari, B., Marais, B. J., Master, I., Brust, J. C. M. Tags: Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Child health, Radiology, Sexual health, Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Unusual chest radiographic findings in children
A 9-year-old British Asian girl with asthma was referred by her general practitioner to outpatients with a 12-month history of dry cough and an abnormal chest radiograph. There was no history of recent travel, tuberculosis (TB) exposure or clinical features to suggest TB such as weight loss and night sweating. She received courses of antibiotics without improvement. She was fully immunised including BCG vaccine. She had chickenpox (varicella) infection aged 3 years. On assessment, she was found to have worsening nocturnal cough, frequent use of inhaled salbutamol, and dyspnoea, wheeze and cough on exertion. Systemic e...
Source: Archives of Disease in Childhood - Education and Practice - September 12, 2014 Category: Pediatrics Authors: Elemraid, M. A., Wacogne, I., Williams, H. Tags: Immunology (including allergy), Drugs: infectious diseases, Child health, Radiology, Asthma, Drugs: respiratory system, Clinical diagnostic tests, Radiology (diagnostics) Epilogue Source Type: research

On the edge of the film...
Question 1 Select one option from the following: Morgagni hernia Intramural gas Spigelian hernia Diaphragmatic eventration Chilaiditi's sign Free intraperitoneal gas Abdominal situs inversus Bochdalek hernia Question 2 Select one option from the following: Atpyical mycobacterial infection Mycoplasma pneumonia Metastatic malignancy Tuberculosis Lymphadenitis Previous BCG vaccination Neuroblastoma Cat scratch disease Introduction Review areas: in radiology these are areas on a radiograph where pathology can be easily overlooked. The term is usually applied to the chest radiograph (CXR) where review areas include behind the h...
Source: Archives of Disease in Childhood - Education and Practice - January 13, 2014 Category: Pediatrics Authors: Williams, H. Tags: Oncology, Oesophagus, Editor's choice, Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Vaccination / immunisation, Child health, Radiology, Clinical diagnostic tests, Radiolo Source Type: research

Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial
Conclusions Through 2 years of blinded treatment in this first head-to-head study between biologic disease-modifying antirheumatic drugs in RA patients with an inadequate response to MTX, subcutaneous abatacept and adalimumab were similarly efficacious based on clinical, functional and radiographic outcomes. Overall, AE frequency was similar in both groups but there were less discontinuations due to AEs, SAEs, serious infections and fewer local ISRs with abatacept. ClinicalTrials.gov Identifier NCT00929864.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Schiff, M., Weinblatt, M. E., Valente, R., van der Heijde, D., Citera, G., Elegbe, A., Maldonado, M., Fleischmann, R. Tags: Open access, Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - May 20, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news