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Rare case of homozygous ifnar1 deficiency in a samoan child with disseminated varicella after vaccination
Autosomal recessive interferon alpha/beta receptor 1 (IFNAR1) deficiency increases susceptibility to live-attenuated vaccines and wild-type viruses. Currently 16 cases, half with Polynesian ancestry have been reported since the discovery in 2019. Most cases present with severe MMR or yellow fever vaccine-related disease. Some cases report severe SARS-CoV-2, herpes simplex, and enterovirus. Varicella vaccine-related disease has been hypothesized but not previously reported.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Revier, N. Scanlon, M. Lee, C. Collins, S. Laubach Tags: M247 Source Type: research

Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis
CONCLUSION: ECRS patients with type 2 inflammation showed decreased ACE2 and TMPRSS2 expressions in their sinus mucosa. ACE2 and TMPRSS2 regulation seems to be positively related to IFN-γ and TNF-α production in CRS patients; ACE2 and TMPRSS2 were co-expressed in the ciliated epithelium of their paranasal mucosa, implicating the paranasal epithelium as a portal for initial infection and transmission.PMID:34989246 | DOI:10.1177/19458924211059639
Source: American Journal of Rhinology and Allergy - January 6, 2022 Category: ENT & OMF Authors: Tomohiro Kawasumi Sachio Takeno Takashi Ishino Tsutomu Ueda Takao Hamamoto Kota Takemoto Yuichiro Horibe Oda Takashi Source Type: research

Investigating the association between allergic diseases and COVID-19 in 400 Iranian patients
CONCLUSION: The results of this study established that allergic diseases were not determined to be a predisposing factor for the severe acute respiratory syndrome (SARS) due to coronavirus 2 (SARS-CoV-2) infection. Significantly, AR patients developed mild clinical manifestations of COVID-19 and admitted to ICU as compared to non-AR patients.PMID:34476916 | DOI:10.15586/aei.v49i5.105
Source: Allergologia et Immunopathologia - September 3, 2021 Category: Allergy & Immunology Authors: Amirhossein Darabi Mohammadrezad Dehghanfard Sara Jozan Rahim Tahmasebi Ali Movahed Marjan Zamani Shokrollah Farrokhi Source Type: research

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