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Specialty: Drugs & Pharmacology
Infectious Disease: Gastroenteritis
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Total 544 results found since Jan 2013.
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Discovery of isatin- β-methyldithiocarbazate derivatives as New Delhi metallo- β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates
Biomed Pharmacother. 2023 Sep 4;166:115439. doi: 10.1016/j.biopha.2023.115439. Online ahead of print.ABSTRACTNew Delhi metallo-β-lactamase-1 (NDM-1) poses a threat to public health due to its capability to hydrolyze nearly all β-lactam antibiotics, leaving limited treatment options for NDM-1 positive pathogens. Regrettably, there are presently no effective NDM-1 inhibitors in clinical use. This compels us to seek new compounds to combat multi-drug resistant bacterial infections (MDR). In our study, Zndm19 was identified as a new NDM-1 inhibitor through virtual screening and an NDM-1 enzyme activity inhibition assay. Subs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 6, 2023 Category: Drugs & Pharmacology Authors: Hongfa Lv Zihao Zhu Chenliang Qian Tianlei Li Zunsheng Han Wenxuan Zhang Xinxin Si Jianfeng Wang Xuming Deng Li Li Tianqi Fang Jie Xia Song Wu Yonglin Zhou Source Type: research
Microbial etiology and antibiotic resistance in urinary tract infections in children; view from an area where antibiotics are overused
CONCLUSIONS: Our study revealed that resistance has developed at very high rates against many oral and parenteral antibiotics that we use in the treatment of UTIs. If our rate of antibiotic use continues to increase this way, it is predicted that UTIs will, unfortunately, become untreatable with oral antibiotics. This upsetting point reached by our country, which is the state that uses antibiotics the most in Europe, exemplifies the importance of rational antibiotic use for the whole world.PMID:37667945 | DOI:10.26355/eurrev_202308_33421
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: S Samanci A S P ınarbaşı Source Type: research
Development of a Novel Histatin-5 Mucoadhesive Gel for the Treatment of Oral Mucositis: In Vitro Characterization and In Vivo Evaluation
AAPS PharmSciTech. 2023 Aug 28;24(7):177. doi: 10.1208/s12249-023-02632-6.ABSTRACTAntimicrobial peptides have appeared to be promising candidates for therapeutic purposes due to their broad antimicrobial activity and non-toxicity. Histatin-5 (Hst-5) is a notable salivary antimicrobial peptide that exhibited therapeutic properties in the oral cavity. Oral mucositis is an acute inflammation of the oral cavity, following cancer therapy. The current treatment methods of oral mucositis have low effectiveness. The aim of this study was to design, formulate and characterize a mucoadhesive gel delivery system for Hst-5 usage in th...
Source: AAPS PharmSciTech - August 28, 2023 Category: Drugs & Pharmacology Authors: Shiva Golshani Alireza Vatanara Saeed Balalaie Zeinab Kadkhoda Mohammad Abdollahi Mohsen Amin Source Type: research
N-unsubstituted Imidazoles: Design, Synthesis, and Antimicrobial Evaluation
CONCLUSION: It is concluded that compound 10 can be acted as a new lead compound to find new azoles antifungal.PMID:37550905 | DOI:10.2174/1381612829666230807120704
Source: Current Pharmaceutical Design - August 8, 2023 Category: Drugs & Pharmacology Authors: Asghar Davood Yassamin EbrahimiNassimi Soroush Sardari Yekta Farmahini Farahani Source Type: research
