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Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations
Penicillium marneffei is a pathogenic fungus endemic in Southeast Asia. P marneffei was an extremely rare pathogen in humans before the HIV epidemic, but following the exponential rise in the prevalence of HIV in Southeast Asia, penicilliosis emerged as a clinically significant opportunistic infection and is classified as an AIDS-defining illness. Less commonly, penicilliosis occurs in patients with other immunodeficiencies, such as severe combined immunodeficiency, common variable immunodeficiency, hyper-IgM syndrome, hyper-IgE syndrome, the presence of anti-IFN-γ autoantibody, diabetes mellitus, immunosuppressive therap...
Source: Journal of Allergy and Clinical Immunology - November 4, 2013 Category: Allergy & Immunology Authors: Pamela P.W. Lee, Huawei Mao, Wanling Yang, Koon-Wing Chan, Marco H.K. Ho, Tsz-Leung Lee, Jasper F.W. Chan, Patrick C.Y. Woo, Wenwei Tu, Yu-Lung Lau Tags: Letters to the Editor Source Type: research