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Source: The Journal of Steroid Biochemistry and Molecular Biology
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Total 26 results found since Jan 2013.
Transcriptome of 17β-hydroxysteroid dehydrogenase type 2 plays both hormone-dependent and hormone-independent roles in MCF-7 breast cancer cells
Publication date: Available online 9 September 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Chen-Yan Zhang, Ezequiel-Luis Calvo, Chang-Qing Yang, Jie Liu, Xiao-Ye Sang, Sheng-Xiang LinAbstractBreast cancer is a major cause of cancer-related death for women in western countries. 17β-Hydroxysteroid dehydrogenases (17β-HSDs) play important roles in the last step of sex-hormone activation and the first step of sex-hormone inactivation. 17β-HSD2 is responsible for oxidizing the sex hormones. We used microarray technology to analyze the effect of 17β-HSD2 on the MCF-7 cell transcript profil...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 10, 2019 Category: Biochemistry Source Type: research
UV increases skin-derived 1α,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol
Publication date: Available online 27 August 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Mi Hee Shin, Yuri Lee, Min-Kyoung Kim, Dong Hun Lee, Jin Ho ChungAbstractThe skin is a unique site in the human body that has the capacity to synthesize the active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), from 7-dehydrocholesterol (7DHC) upon UV irradiation. Keratinocytes express both 25-hydroxylase (CYP27A1 and CYP2R1) and 1α-hydroxylase (CYP27B1), critical enzymes involved in active vitamin D synthesis. Here, we investigated the effect of skin-derived 1α,25(OH)2D3, synthesiz...
Source: The Journal of Steroid Biochemistry and Molecular Biology - August 28, 2019 Category: Biochemistry Source Type: research
Cardiotonic steroid ouabain stimulates steroidogenesis in Leydig cells via the α3 isoform of the sodium pump
Publication date: Available online 28 April 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Neha Upmanyu, Raimund Dietze, Ahmed Bulldan, Georgios Scheiner-BobisAbstractCardiotonic steroids such as ouabain are potent inhibitors of the sodium pump and have been widely used for centuries in the treatment of congestive heart failure. In recent decades, however, they have also been identified as hormone-like molecules that trigger signaling cascades of physiological relevance by using the various sodium pump α subunit isoforms as receptors. The murine Leydig cell line MLTC-1 expresses both the u...
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 29, 2019 Category: Biochemistry Source Type: research
Age-dependent expression of the Vitamin D receptor and the protective effect of Vitamin D receptor activation on H2O2-induced apoptosis in rat intervertebral disc cells
Publication date: Available online 21 March 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Tong Tong, Zhihui Liu, Hua Zhang, Jinglei Sun, Dongxia Zhang, Feng Wang, Dechao Miao, Yong ShenAbstractAccumulating evidence shows that genetic polymorphism of the vitamin D receptor (VDR) gene is associated with intervertebral disc degeneration (IDD), implying that VDR may be involved in the pathogenesis of IDD. However, the exact relationship between VDR and IDD remains unknown. The aim of this study was to investigate the age-dependent expression of VDR in rat intervertebral discs and to determine ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - March 22, 2019 Category: Biochemistry Source Type: research
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
Publication date: Available online 12 February 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Nikolaos Nikolaou, Laura L Gathercole, Lucy Kirkwood, James E Dunford, Beverly A. Hughes, Lorna C. Gilligan, Udo Oppermann, Trevor M. Penning, Wiebke Arlt, Leanne Hodson, Jeremy W. TomlinsonAbstractSteroid hormones, including glucocorticoids and androgens, have potent actions to regulate many cellular processes within the liver. The steroid A-ring reductase, 5β-reductase (AKR1D1), is predominantly expressed in the liver, where it inactivates steroid hormones and, in addition, plays a crucial role ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - February 13, 2019 Category: Biochemistry Source Type: research
Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization
Publication date: Available online 31 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Maria M. Szwarc, Lan Hai, William E. Gibbons, Qianxing Mo, Rainer B. Lanz, Francesco J. DeMayo, John P. LydonAbstractMouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellular processes in human is unclear. Analysis of clinical samples indicate that endometrial EGR1 levels are decreased in the endometrium of...
Source: The Journal of Steroid Biochemistry and Molecular Biology - February 1, 2019 Category: Biochemistry Source Type: research
SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRα pathways in bovine ovarian granular cells
Publication date: Available online 7 August 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Dejun Xu, Huanshan He, Xiaohan Jiang, Rongmao Hua, Huali Chen, Li Yang, Jianyong Cheng, Jiaxin Duan, Qingwang LiAbstractSIRT2 has been shown to possess NAD+-dependent deacetylase and desuccinylase enzymatic activities, it also regulates metabolism homeostasis in mammals. Previous data has suggested that resveratrol, a potential activator of Sirtuins, played a stimulation role in steroidogenesis. Unfortunately, to date, the physiological roles of SIRT2 in ovarian granular cells (GCs) are largely unknow...
Source: The Journal of Steroid Biochemistry and Molecular Biology - August 8, 2018 Category: Biochemistry Source Type: research
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research
Molecular mechanisms underlying progesterone-induced cytoplasmic retention of p27 in breast cancer cells
Publication date: Available online 27 June 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Hui-Chen Wang, Wen-Sen LeeAbstractIt has been reported that progesterone (P4) can contribute to the aggressiveness of human breast cancers through promoting cytoplasmic localization of p27 and stimulating proliferation. However, the molecular mechanisms underlying P4-induced cytoplasmic retention of p27 are still unclear. Here, we demonstrated that P4 (12.5–100 nM) concentration-dependently increased the number of T47D and MCF-7 cells. P4 (50 nM) also time-dependently increased the levels of p27 ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research
Impairment of the Gnα11-controlled expression of claudin-1 and MMP-9 and collective migration of human breast cancer MCF-7 cells by DHEAS
Publication date: Available online 21 April 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Neha Upmanyu, Ahmed Bulldan, Dimitrios Papadopoulos, Raimund Dietze, Viveka Nand Malviya, Georgios Scheiner-BobisAbstractAlthough dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. We address here DHEAS effects on the estrogen receptor-positive metastatic human breast cancer cell line MCF-7. We focus on DHEAS-mediated signaling that might influence expression of claudin-1 and matrix metalloproteinase-9 (MMP-...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 5, 2018 Category: Biochemistry Source Type: research
Molecular mechanisms underlying progesterone-induced cytoplasmic retention of p27 in breast cancer cells
Publication date: Available online 27 June 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Hui-Chen Wang, Wen-Sen LeeAbstractIt has been reported that progesterone (P4) can contribute to the aggressiveness of human breast cancers through promoting cytoplasmic localization of p27 and stimulating proliferation. However, the molecular mechanisms underlying P4-induced cytoplasmic retention of p27 are still unclear. Here, we demonstrated that P4 (12.5–100 nM) concentration-dependently increased the number of T47D and MCF-7 cells. P4 (50 nM) also time-dependently increased the levels of p27 ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 5, 2018 Category: Biochemistry Source Type: research
Impairment of the Gn α11-controlled expression of claudin-1 and MMP-9 and collective migration of human breast cancer MCF-7 cells by DHEAS
Publication date: Available online 21 April 2018 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Neha Upmanyu, Ahmed Bulldan, Dimitrios Papadopoulos, Raimund Dietze, Viveka Nand Malviya, Georgios Scheiner-Bobis Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. We address here DHEAS effects on the estrogen receptor-positive metastatic human breast cancer cell line MCF-7. We focus on DHEAS-mediated signaling that might influence expression of claudin-1 and matrix metalloproteinase-9 (MMP-9), b...
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 21, 2018 Category: Biochemistry Source Type: research
