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Source: The Journal of Allergy and Clinical Immunology: In Practice
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Natural History of Benign Nonimmediate Allergy to Beta-Lactams in Children: A Prospective Study in Retreated Patients After a Positive and a Negative Provocation Test
ConclusionsOur data strongly suggest that a fuDPT is safe and useful to assess tolerance acquisition in children with a confirmed benign nonimmediate BL allergy. In addition, our results support the use of a short DPT protocol (2 days), which led to a high NPV of 96.7% in our population, with a favorable benefit-risk balance.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 10, 2018 Category: Allergy & Immunology Source Type: research
Children with East Asian-born parents have an increased risk of allergy but may not have more asthma in early childhood
ConclusionsChildren of East Asian ancestry born in Australia have a higher burden of most allergic diseases in the first 6 years of life, while asthma may follow a different pattern. IgE-mediated food allergy and eczema at age 1 increase the risk of asthma and allergic rhinitis irrespective of ancestry.
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 24, 2018 Category: Allergy & Immunology Source Type: research
Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thomas B. Casale, Tmirah Haselkorn, Christina E. Ciaccio, Panida Sriaroon, Bradley E. ChippsAbstractCurrently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic pu...
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 15, 2018 Category: Allergy & Immunology Source Type: research
A Retrospective Critical Analysis and Risk Stratification of Penicillin Allergy Delabeling in a UK Specialist Regional Allergy Service
ConclusionsSystematic clinical characterization and risk stratification has an important role in Pen-A delabeling. These data provide proof of concept for a guideline-based selection of patients labeled with Pen-A for a direct penicillin challenge. Patients in the “low risk” group seem suitable for this intervention, although a rigorous prospective evaluation is needed in a multicenter study.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 29, 2018 Category: Allergy & Immunology Source Type: research
Investigation into the α-Gal syndrome: Characteristics of 261 children and adults reporting red meat allergy
ConclusionsThe α-Gal syndrome is a regionally common form of food allergy that: has a characteristic but not universal delay in symptom onset; includes gastrointestinal symptoms; can develop at any time in life; and, is equally common in otherwise non-atopic individuals.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 31, 2019 Category: Allergy & Immunology Source Type: research
Innovations in Health Care Delivery: Drug Allergy
Publication date: Available online 17 May 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Allison Ramsey, Aziz SheikhAbstractThis review focuses on advances in health information technology (HIT) in the detection, diagnosis, and management of drug allergy. The data regarding the use of electronic health records (EHR) and social media for the detection of drug allergy is reviewed, along with predictive algorithms and clinical decision support systems for drug allergy diagnosis. Drug allergy pathways, algorithms, CDSS (computerized decision support systems), and CPOE (computerized physician ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 17, 2019 Category: Allergy & Immunology Source Type: research
The Prevalence of Food Allergy in Young Israeli Adults
ConclusionsThe prevalence of FA among Israeli young adults is lower than reported for other western countries. Reliance on food elimination alone does not accurately rule in FA. The use of the identified predictors for FA can facilitate large scale epidemiological studies in adults.
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 7, 2019 Category: Allergy & Immunology Source Type: research
COLA (Conferences On-Line Allergy) at 10 Years—Evolution of an Online Fellowship Curriculum
Publication date: Available online 4 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paul J. Dowling, Rubin Kader, Jay` M. PortnoyAbstractOnline learning has been present since the early days of the Internet. As with any new technology, users look to make their life easier and to save time. Experts in medical education are no different than other users. They want to adapt new technologies to their fullest. Medical educators have been challenged with keeping education interesting and up to date, while maximizing their resources. The challenges with any online educational program includ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 5, 2019 Category: Allergy & Immunology Source Type: research
COLA (Conferences On-Line Allergy) at 10 Years — Evolution of an Online Fellowship Curriculum
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Paul J. Dowling, Rubin Kader, Jay M. PortnoyOnline learning has been present since the early days of the Internet. As with any new technology, users look to make their life easier and to save time. Experts in medical education are no different than other users. They want to adapt new technologies to their fullest. Medical educators have been challenged with keeping education interesting and up to date, while maximizing their resources. The challenges with any online educational program ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research
A streamlined approach to optimize perioperative antibiotic prophylaxis in the setting of penicillin allergy labels
ConclusionUsing a streamlined algorithm, we were able to significantly reduce the use of second-line antibiotics in penicillin-allergic surgical patients without severe adverse reactions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 28, 2019 Category: Allergy & Immunology Source Type: research
Allergy evaluation of hypersensitivity to platinium salts and taxanes: a six-year experience.
ConclusionsST to PS or TX offered a high NPV, making allergy evaluation a key element in the management of cancer patients. Graded challenges can be safely performed by oncology teams trained in anaphylaxis management.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 7, 2020 Category: Allergy & Immunology Source Type: research
Baked Milk- and Egg-Containing Diet in the Management of Milk and Egg Allergy
Publication date: January–February 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 3, Issue 1 Author(s): Stephanie A. Leonard , Jean-Christoph Caubet , Jennifer S. Kim , Marion Groetch , Anna Nowak-Węgrzyn Cow's milk (CM) and hen's egg allergies are among the most common food allergies in children. With evidence of increasing food allergy prevalence and more persistent disease, it has become vital to improve the management of CM and egg allergies. The ability to tolerate baked milk or egg, such as in a cake or muffin, has been associated with an increased chance of tolerance development...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 7, 2015 Category: Allergy & Immunology Source Type: research
Epinephrine Use in Positive Oral Food Challenges Performed as Screening Test for Food Allergy Therapy Trials
Conclusions Screening OFCs to confirm food allergies can be performed safely, but there was a higher rate of epinephrine use compared with OFCs used for assessing food allergy outgrowth. Therefore, personnel skilled and experienced in the recognition of early signs and symptoms of anaphylaxis who can promptly initiate treatment are required.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 14, 2015 Category: Allergy & Immunology Source Type: research
Molecular Diagnosis of Shrimp Allergy: Efficiency of Several Allergens to Predict Clinical Reactivity
Conclusion Tropomyosin and sarcoplasmic-calcium-binding-protein sensitization is associated with clinical reactivity to shrimp. Myosin light chain testing may help in the diagnosis of clinical reactivity. Arginine kinase and hemocyanin appear to be cross-reacting allergens between shrimp and arthropods. Detection of IgE to these allergens and some of their epitopes may be better diagnostic tools in the routine workup of shrimp allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 13, 2015 Category: Allergy & Immunology Source Type: research
Stinging Insect Allergy: State of the Art 2015
Publication date: May–June 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 3, Issue 3 Author(s): Michael S. Tankersley , Dennis K. Ledford Stinging insect allergy is responsible for more than 10% of all cases of anaphylaxis. The potential culprit insects are diverse and vary with geography. The incidence of insect allergy is declining in some areas and increasing in others, possibly due to effects of climate change, introduction of species into new areas, outdoor recreational activities, and movement of human populations that brings insects into contact with a greater number of people. F...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 5, 2015 Category: Allergy & Immunology Source Type: research
