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Source: International Journal of Molecular Medicine

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Total 198 results found since Jan 2013.

Distal-less homeobox 5 is a master regulator of the osteogenesis of human mesenchymal stem cells.
Abstract Mesenchymal stem cells (MSCs) differentiate into multiple lineages and are a promising source of cells for clinical use. Previously, we found that the gene distal‑less homeobox 5 (DLX5) is specifically expressed in MSCs with osteogenic potential. Understanding the mechanism of osteogenesis is necessary for successful bone regeneration using MSCs. The aim of this study was to examine the function of the DLX5 gene in MSCs during osteogenesis (bone development). We analyzed the possible association between DLX5 expression and osteogenesis-, chondrogenesis- and adipogenesis-related gene expression in diff...
Source: International Journal of Molecular Medicine - September 19, 2017 Category: Molecular Biology Authors: Heo JS, Lee SG, Kim HO Tags: Int J Mol Med Source Type: research

PKC ζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds.
In this study, we provide evidence that PKCζ mediates lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNFα) gene expression in the mouse macrophage cell line, RAW264.7. TNFα has been proven to be one of the main culprits of chronic wounds and impaired acute wounds, which are characterized by excessive inflammation, enhanced proteolysis and reduced matrix deposition. Among the multiple effects of TNFα on keratinocytes, the induction of chemokines which are indispensable factors involved in the massive infiltration of various inflammatory cells into skin lesions serves as a crucial mechanism. In the present...
Source: International Journal of Molecular Medicine - September 20, 2017 Category: Molecular Biology Authors: Zhang J, Yang X, Wang H, Zhao B, Wu X, Su L, Xie S, Wang Y, Li J, Liu J, Liu M, Han F, He T, Zhang W, Tao K, Hu D Tags: Int J Mol Med Source Type: research

Long non ‑coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway.
Long non‑coding RNA DANCR regulates the proliferation and osteogenic differentiation of human bone-derived marrow mesenchymal stem cells via the p38 MAPK pathway. Int J Mol Med. 2017 Oct 27;: Authors: Zhang J, Tao Z, Wang Y Abstract Long non-coding RNAs (lncRNAs) have been established to participate in the complex network of various biological processes and play important roles in the differentiation of mesenchymal stem cells (MSCs). However, the roles of lncRNAs in the mechanisms of the osteogenic differentiation of human bone marrow-derived MSCs (HBMSCs) are poorly understood. Thus, this study...
Source: International Journal of Molecular Medicine - October 27, 2017 Category: Molecular Biology Authors: Zhang J, Tao Z, Wang Y Tags: Int J Mol Med Source Type: research

Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF- α-induced ICAM-1 expression and NF-κB activation in endothelial cells.
Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells. Int J Mol Med. 2017 Nov 07;: Authors: Chen LG, Zhang YQ, Wu ZZ, Hsieh CW, Chu CS, Wung BS Abstract Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory effect of arachidin-1 in endothelial cells (ECs). The results of cell adhesion and western blotting assays demonstrated that ara...
Source: International Journal of Molecular Medicine - November 7, 2017 Category: Molecular Biology Authors: Chen LG, Zhang YQ, Wu ZZ, Hsieh CW, Chu CS, Wung BS Tags: Int J Mol Med Source Type: research

Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial‑to‑mesenchymal transition via JAK/STAT3 signaling.
Abstract Transforming growth factor β1 (TGFβ1) is a cytokine with multiple functions. TGFβ1 significantly induces migration and invasion of liver cancer cells. However, the molecular mechanisms underlying this effect remain unclear. Epithelial‑to‑mesenchymal transition (EMT) is crucial for the development of invasion and metastasis in human cancers. The aim of the present study was to determine whether TGFβ1‑induced EMT promoted migration and invasion in HepG2 cells. The underlying mechanism and the effect of EMT on HepG2 cells were also investigated. The results demonstrated that TGFβ1 may induce EMT t...
Source: International Journal of Molecular Medicine - November 1, 2017 Category: Molecular Biology Authors: Lin XL, Liu M, Liu Y, Hu H, Pan Y, Zou W, Fan X, Hu X Tags: Int J Mol Med Source Type: research

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome.
Abstract Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase rele...
Source: International Journal of Molecular Medicine - December 5, 2017 Category: Molecular Biology Authors: Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW, Hsu YL Tags: Int J Mol Med Source Type: research

Macrophage migration inhibitory factor promotes Warburg effect via activation of the NF ‑κB/HIF‑1α pathway in lung cancer.
In conclusion, the findings of the present study demonstrated that MIF is a key component in lung cancer progression through promoting the Warburg effect, and that the novel MIF/NF‑κB/HIF‑1α axis may prove to be useful for the development of new strategies for treating patients with lung cancer. PMID: 29207023 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - November 22, 2017 Category: Molecular Biology Authors: Li J, Zhang J, Xie F, Peng J, Wu X Tags: Int J Mol Med Source Type: research

Co-expression network analysis of lncRNAs and mRNAs in OPTN-silenced cells.
In conclusion, the abnormal lncRNAs identified in OPTN-silenced cells indicate that lncRNAs may contribute to the molecular pathogenesis of OPTN-associated diseases. PMID: 29251316 [PubMed - in process]
Source: International Journal of Molecular Medicine - December 20, 2017 Category: Molecular Biology Authors: Jin L, Li Y, Zhou X, Yuan H Tags: Int J Mol Med Source Type: research

The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway.
Abstract cMaf is a leucine-zipper transcription factor that is involved in cell differentiation, oncogenic transformation, and human diseases; however, the functions of cMaf in inflammatory responses in macrophages are still not fully understood. Western blot analysis showed that cMaf expression was induced by lipopolysaccharide (LPS) stimulation in mouse macrophages. An enzyme-linked immunosorbent assay was performed to detect the level of expression of inflammatory cytokines after knockdown of cMaf expression in macrophages using a small interfering RNA (siRNA). Signaling pathway inhibitor analyses indicated tha...
Source: International Journal of Molecular Medicine - February 23, 2018 Category: Molecular Biology Authors: Wang Y, Luan C, Zhang G, Sun C Tags: Int J Mol Med Source Type: research

Interfering RNA with multi-targets for efficient gene suppression in HCC cells.
Abstract RNA interference (RNAi) technology has been widely used in therapeutics development, especially multiple targeted RNAi strategy, which is a better method for multiple gene suppression. In the study, interfering RNAs (iRNAs) were designed for carrying two or three different siRNA sequences in different secondary structure formats (loop or cloverleaf). By using these types of iRNAs, co-inhibition of survivin and B-cell lymphoma-2 (Bcl-2) was investigated in hepatocellular carcinoma (HCC) cells, and we obtained promising gene silencing effects without showing undesirable interferon response. Furthermore, su...
Source: International Journal of Molecular Medicine - March 9, 2018 Category: Molecular Biology Authors: Li T, Zhu YY, Ji Y, Zhou S Tags: Int J Mol Med Source Type: research

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF ‑R.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R. Int J Mol Med. 2018 Mar 09;: Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Abstract The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac f...
Source: International Journal of Molecular Medicine - March 9, 2018 Category: Molecular Biology Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Tags: Int J Mol Med Source Type: research

Expression of annexin  II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer.
In conclusion, the results demonstrated that ANX2 and stromal TNC regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of PDAC. These results indicate the potential of the ANX2‑TNC axis as a therapeutic target for PDAC metastasis. PMID: 29749431 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - May 2, 2018 Category: Molecular Biology Authors: Yoneura N, Takano S, Yoshitomi H, Nakata Y, Shimazaki R, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M Tags: Int J Mol Med Source Type: research

Hypoxia ‑induced expression of CXCR4 favors trophoblast cell migration and invasion via the activation of HIF‑1α.
Hypoxia‑induced expression of CXCR4 favors trophoblast cell migration and invasion via the activation of HIF‑1α. Int J Mol Med. 2018 May 22;: Authors: Zhang Z, Li P, Wang Y, Yan H Abstract The placenta initially develops in a low‑oxygen environment up to week 8‑10 of gestation, and a low oxygen level is a critical factor in the regulation of trophoblast migration and invasion. CXC chemokine receptor 4 (CXCR4) is transcriptionally activated by hypoxia in cancer cells. However, whether CXCR4 is involved in hypoxia‑inducible factor (HIF)‑1α‑dependent trophoblastic migration and invasion i...
Source: International Journal of Molecular Medicine - May 22, 2018 Category: Molecular Biology Authors: Zhang Z, Li P, Wang Y, Yan H Tags: Int J Mol Med Source Type: research

MicroRNA ‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury.
MicroRNA‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury. Int J Mol Med. 2018 May 18;: Authors: Liang ZG, Yao H, Xie RS, Gong CL, Tian Y Abstract Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)‑20b‑5p has been demonstrated to be involved in malignancies of the breast, colorectum, stomach, blood and oropharynx. The present study aimed to investigate the effects of ...
Source: International Journal of Molecular Medicine - May 18, 2018 Category: Molecular Biology Authors: Liang ZG, Yao H, Xie RS, Gong CL, Tian Y Tags: Int J Mol Med Source Type: research

MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression.
In conclusion, these data prove that the overexpression of miR-137 was associated with an altered risk of fracture in patients with osteoporosis, and can be used as a biomarker for the prediction of risk of fracture in osteoporosis. PMID: 29786747 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - May 17, 2018 Category: Molecular Biology Authors: Liu X, Xu X Tags: Int J Mol Med Source Type: research