Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer.

In conclusion, the results demonstrated that ANX2 and stromal TNC regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of PDAC. These results indicate the potential of the ANX2‑TNC axis as a therapeutic target for PDAC metastasis. PMID: 29749431 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29749431?dopt=Abstract

Source: International Journal of Molecular Medicine - May 2, 2018 Category: Molecular Biology Authors: Yoneura N, Takano S, Yoshitomi H, Nakata Y, Shimazaki R, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M Tags: Int J Mol Med Source Type: research