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Source: Cardiovascular Research
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Total 52 results found since Jan 2013.
Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury
ConclusionThese studies identify a truncated form of YY1 (YY1B) that can interact with BASP1 and inhibit SMC proliferation, migration, and intimal hyperplasia after balloon injury of rat carotid arteries as effectively as full length YY1. We demonstrate the therapeutic potential of YY1B in vascular proliferative disease.
Source: Cardiovascular Research - January 28, 2021 Category: Cardiology Source Type: research
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis
ConclusionThese findings demonstrate that RSPO2 inhibits lymphangiogenesis via LGR4 and downstream impairment of AKT-eNOS-nitric oxide signalling. These results may also inform new therapeutic strategies to promote lymphangiogenesis and improve cholesterol efflux from atherosclerotic arteries.
Source: Cardiovascular Research - August 4, 2020 Category: Cardiology Source Type: research
The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease
ConclusionArterial stiffness promotes EC dysfunction and vascular disease at least partly through the suppression of the glycocalyx protein Glypican 1. Glypican 1 contributes to the protection against endothelial cell dysfunction and vascular disease in endothelial cells.
Source: Cardiovascular Research - July 9, 2020 Category: Cardiology Source Type: research
Insights from ORION studies: focus on inclisiran safety
This editorial refers to ‘Effect of inclisiran, the siRNA against PCSK9, on platelets, immune cells and immunological biomarkers—a pre-specified analysis from ORION-1’ by U. Landmesseret al., pp. 284 –291.
Source: Cardiovascular Research - May 13, 2020 Category: Cardiology Source Type: research
Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1
Conclusion In this pre-specified safety analysis of ORION-1 for the siRNA therapeutic inclisiran, no adverse effects on measures of inflammation or immune activation nor adverse effects on platelets or clinical immunogenicity AEs were observed over at least 6-month treatment. These safety findings in the largest analysis of an RNAi study in humans to date provide strong reassurance about the safety of inclisiran and the potential of cardiovascular RNA-targeted therapies.
Source: Cardiovascular Research - April 3, 2020 Category: Cardiology Source Type: research
Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease
ConclusionsWe identified RGS5 as a novel susceptibility gene for CAD and showed that the decreased expression of RGS5 impaired endothelial cell function and functionally contributed to atherosclerosis through a variety of molecular mechanisms. How RGS5 regulates the expression of CXCL12 needs further studies.
Source: Cardiovascular Research - October 12, 2019 Category: Cardiology Source Type: research
Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research
PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
ConclusionsThis study shows that in an inflammatory milieu, elevated levels of PCSK9 potently stimulate the expression of SRs (principally LOX-1) and ox-LDL uptake in macrophages, and thus contribute to the process of atherogenesis.
Source: Cardiovascular Research - March 29, 2018 Category: Cardiology Source Type: research
HDAC4 regulates vascular inflammation via activation of autophagy
ConclusionThese results suggest that HDAC4-mediated FoxO3a acetylation regulates Ang II-induced autophagy activation, which in turn plays an essential role in causing vascular inflammation.
Source: Cardiovascular Research - February 24, 2018 Category: Cardiology Source Type: research
Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKII δ expression in the aged atrium
ConclusionJNK2 activation up-regulates CaMKII δ expression in the aged atrium. This JNK2 regulation in CaMKIIδ expression occurs at the transcription level through the JNK downstream transcription factor c-jun. The discovery of this novel molecular mechanism of JNK2-regulated CaMKII expression sheds new light on possible anti-arrhythmia drug development.
Source: Cardiovascular Research - January 19, 2018 Category: Cardiology Source Type: research
Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury
ConclusionLoss of PKN1in vivo significantly reduces endogenous cardioprotection and increases myocardial infarct size following I/R injury. Cardioprotection by PKN1 is associated with reduced CamKII δ-dependent PLB Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity.
Source: Cardiovascular Research - October 16, 2017 Category: Cardiology Source Type: research
Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF- κB and AP-1 signalling
ConclusionSPL has important anti-inflammatory effects independent of aldosterone and MR, not shared with EPL. Drug-induced, proteasome-dependent XPB degradation may be a useful therapeutic approach in cardiovascular diseases driven by inflammation.
Source: Cardiovascular Research - September 27, 2017 Category: Cardiology Source Type: research
Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKC α signalling and cross-talk with TGFβ
ConclusionThis is the first demonstration that syndecan-4 promotes FGF-2 signalling, and in turn, suppresses VSMC mineralization by down-regulating TGF β signalling. Our discoveries that FGF-2 and syndecan-4 expression is increased in mineralizing VSMCs and that PKCα regulates FGF-2 and TGFβ signalling in VSMCs suggests that the syndecan-4/FGF-2/TGFβ signalling axis could represent a new therapeutic target for vascular calcification.
Source: Cardiovascular Research - September 6, 2017 Category: Cardiology Source Type: research
Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction
ConclusionOur data indicate a novel interplay between ROCK and [Ca2+]i signalling in HPV via PTEN, in that ROCK mediates interaction of PTEN and TRPC6 which then conjointly translocate to caveolae allowing for Ca2+ influx into and subsequent contraction of PASMC.
Source: Cardiovascular Research - April 18, 2017 Category: Cardiology Source Type: research
Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis
Conclusions</div>Our results demonstrate a novel mechanism for the regulation of VSMC differentiation by MIF involving p68 and SRF. Strategy for targeting of MIF could inhibit aberrant transition of VSMC in cardiovascular pathogenesis, and may be of therapeutic benefit in phenotype-related arterial remodelling.</span>
Source: Cardiovascular Research - February 27, 2017 Category: Cardiology Source Type: research
