Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKII δ expression in the aged atrium

ConclusionJNK2 activation up-regulates CaMKII δ expression in the aged atrium. This JNK2 regulation in CaMKIIδ expression occurs at the transcription level through the JNK downstream transcription factor c-jun. The discovery of this novel molecular mechanism of JNK2-regulated CaMKII expression sheds new light on possible anti-arrhythmia drug development.
Source: Cardiovascular Research - Category: Cardiology Source Type: research