Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction

ConclusionOur data indicate a novel interplay between ROCK and [Ca2+]i signalling in HPV via PTEN, in that ROCK mediates interaction of PTEN and TRPC6 which then conjointly translocate to caveolae allowing for Ca2+ influx into and subsequent contraction of PASMC.
Source: Cardiovascular Research - Category: Cardiology Source Type: research