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Source: Vascular Pharmacology

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Total 31 results found since Jan 2013.

MCU-dependent mitochondrial calcium uptake-induced mitophagy contributes to apelin-13-stimulated VSMCs proliferation
Vascul Pharmacol. 2022 Mar 16:106979. doi: 10.1016/j.vph.2022.106979. Online ahead of print.ABSTRACTApelin is an endogenous ligand of the G protein-coupled receptor APJ. Both apelin and APJ receptors, which are expressed in vascular smooth muscle cells (VSMCs), play important roles in the cardiovascular system. Our previous studies researches indicated that mitophagy mediated apelin-13-induced VSMCs proliferation. However, little is known about how apelin-13 regulates mitophagy to participate in VSMC proliferation. The results of the present study demonstrated that mitochondrial calcium uniporter (MCU) uptake-dependent mit...
Source: Vascular Pharmacology - March 20, 2022 Category: Drugs & Pharmacology Authors: Zhe Chen Qionglin Zhou Jun Chen Yiyuan Yang Wei Chen Hui Mao Xueqian Ouyang Kai Zhang Mingzhu Tang Jialong Yan Linzhi Wang Linxi Chen Lanfang Li Source Type: research

TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm
CONCLUSION: These findings suggested that Cav-1, which was upregulated by TLR4-Myd88, served as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.PMID:34822994 | DOI:10.1016/j.vph.2021.106947
Source: Vascular Pharmacology - November 25, 2021 Category: Drugs & Pharmacology Authors: Xin Zhao Jinfan Tian Yue Liu Zhishuai Ye Mingyue Xu Rongchong Huang Xiantao Song Source Type: research

Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration
Vascul Pharmacol. 2021 Mar 29:106860. doi: 10.1016/j.vph.2021.106860. Online ahead of print.ABSTRACT5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporter and receptors plays important roles in chronic hypoxic pulmonary hypertension (CHPH), which is associated with aberrant reactive oxygen species (ROS) production. NADPH oxidase 4 (NOX4) is one of the major sources of ROS in pulmonary vasculature, and has been implicated in the development of PH. NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and ...
Source: Vascular Pharmacology - April 1, 2021 Category: Drugs & Pharmacology Authors: Jia-Lin Song Si-Yi Zheng Rui-Lan He Long-Xin Gui Mo-Jun Lin James S K Sham Source Type: research

Arg mediates LPS-induced disruption of the pulmonary endothelial barrier.
Abstract Acute Respiratory Distress Syndrome (ARDS) is a devastating disease process that involves dysregulated inflammation and decreased alveolar-capillary barrier function. Despite increased understanding of the pathophysiology, no effective targeted therapies exist to treat ARDS. Recent preclinical studies suggest that the multi-tyrosine kinase inhibitor, imatinib, which targets the Abl kinases c-Abl and Arg, has the potential to restore endothelial dysfunction caused by inflammatory agonists. Prior work demonstrates that imatinib attenuates LPS (lipopolysaccharide)-induced vascular leak and inflammation; howe...
Source: Vascular Pharmacology - March 29, 2020 Category: Drugs & Pharmacology Authors: Rizzo AN, Belvitch P, Demeritte R, Garcia JGN, Letsiou E, Dudek SM Tags: Vascul Pharmacol Source Type: research

HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression.
Abstract Receptors for advanced glycation end-product (RAGE) play a pivotal role in the progression of proliferative vascular diseases. However, the precise mechanisms regulating RAGE expression in vascular smooth muscle cells (VSMCs) of the injured vasculatures is unclear. Given the potential importance of 5-lipoxygenase (5-LO) derived mediators in cellular responses mediated by RAGE, this study aimed to evaluate in VSMCs treated with high mobility group box 1 (HMGB1): 1) the RAGE expression; 2) the AGE-induced VSMC proliferation; 3) the role of 5-LO signaling in HMGB1-induced RAGE expression. In cultured human V...
Source: Vascular Pharmacology - April 3, 2019 Category: Drugs & Pharmacology Authors: Jang EJ, Baek SE, Kim EJ, Park SY, Kim CD Tags: Vascul Pharmacol Source Type: research

Nox4 and soluble epoxide hydrolase synergistically mediate homocysteine-induced inflammation in vascular smooth muscle cells.
CONCLUSIONS: The inflammatory response induced by homocysteine in VSMCs was accompanied by Nox4 and sEH upregulation. Nox4 and soluble epoxide hydrolase synergistically contribute to homocysteine-induced inflammation. PMID: 30610956 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - January 2, 2019 Category: Drugs & Pharmacology Authors: Liu X, Qin Z, Liu C, Song M, Luo X, Zhao H, Qian D, Chen J, Huang L Tags: Vascul Pharmacol Source Type: research

Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
In conclusion, ADMA contributes to the neovascularization of retina in diabetic mellitus, which is regulated by ephrinB2. PMID: 29777874 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - May 16, 2018 Category: Drugs & Pharmacology Authors: Du MR, Yan L, Li NS, Wang YJ, Zhou T, Jiang JL Tags: Vascul Pharmacol Source Type: research

A positive feedback loop between IL-1 β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages.
A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Vascul Pharmacol. 2018 Jan 22;: Authors: Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D Abstract Inflammation plays an important role in atherosclerosis, a notion supported by the beneficial effects of the IL-1β inhibitor canakinumab in the CANTOS trial. Sialic acids (Sias), components of the surface glycocalyx, regulate intercellular and intermolecular interactions. We investigated ...
Source: Vascular Pharmacology - January 22, 2018 Category: Drugs & Pharmacology Authors: Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D Tags: Vascul Pharmacol Source Type: research