TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm

CONCLUSION: These findings suggested that Cav-1, which was upregulated by TLR4-Myd88, served as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.PMID:34822994 | DOI:10.1016/j.vph.2021.106947

Source: Vascular Pharmacology - November 25, 2021 Category: Drugs & Pharmacology Authors: Xin Zhao Jinfan Tian Yue Liu Zhishuai Ye Mingyue Xu Rongchong Huang Xiantao Song Source Type: research