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Specialty: Food Science
Source: Food and Chemical Toxicology

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Total 46 results found since Jan 2013.

Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3 β/β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231
Food Chem Toxicol. 2021 Sep 15:112574. doi: 10.1016/j.fct.2021.112574. Online ahead of print.ABSTRACTGolgi Membrane Protein 1 (GOLM1) has been identified as a prime target for cancer therapy because it overexpresses in many solid tumors, increases tumor growth and metastasis and leads to unfavorable survival. Though various approaches including siRNA interference and antibody targeting have been attempted, GOLM1 has remained an un-targetable molecule because of its mainly intracellular location and the lack of domains that could possibly be interfered with by small molecules. Numerous natural anti-tumoral plant substances ...
Source: Food and Chemical Toxicology - September 18, 2021 Category: Food Science Authors: Ling Xie Jun Yi Yongjia Song Mengyao Zhao Liqiang Fan Liming Zhao Source Type: research

Perfluorooctane sulfonate induces autophagy-dependent lysosomal membrane permeabilization by weakened interaction between tyrosinated alpha-tubulin and spinster 1
This study pointed out that SPNS1-tyrosinated α-tubulin interaction mediated the cross-talk between autophagy and LMP induced by PFOS, shedding new light on the mechanism of PFOS hepatotoxicity.PMID:34500008 | DOI:10.1016/j.fct.2021.112540
Source: Food and Chemical Toxicology - September 9, 2021 Category: Food Science Authors: Zhanchen Dong Tianming Qiu Jingyuan Zhang Shanshan Sha Xiuyan Han Jian Kang Xiaoxia Shi Xiance Sun Liping Jiang Guang Yang Xiaofeng Yao Yufang Ma Source Type: research

Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis
Food Chem Toxicol. 2021 Mar 21:112134. doi: 10.1016/j.fct.2021.112134. Online ahead of print.ABSTRACTT-2 toxin, a food-derived mycotoxin, has been identified as a neurotoxin. Nonetheless, T-2 toxin-induced neuroinflammation has never been revealed. As an important therapeutic target for inflammatory diseases and cancers, the role of high mobility group B1 (HMGB1) in mycotoxin-mediated neurotoxicity remains a mystery. In current study, we found that PC12 cells were sensitive to trace amounts of T-2 toxin less than 12 ng/mL, distinguished by decreased cell viability and increased release of lactate dehydrogenase (LDH). Oxida...
Source: Food and Chemical Toxicology - March 25, 2021 Category: Food Science Authors: Xingyao Pei Haiyang Jiang Xinyu Liu Liuan Li Cun Li Xilong Xiao Daowen Li Shusheng Tang Source Type: research

IRE1 and CaMKK β pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells.
This study is the first study revealing the molecular mechanisms of MC-LR-induced autophagy of ovarian cells and providing new insights into the female reproductive toxicity of MC-LR. PMID: 33290805 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - December 5, 2020 Category: Food Science Authors: Ma Y, Liu H, Du X, Petlulu P, Chen X, Wang R, Zhang S, Tian Z, Shi L, Guo H, Zhang H Tags: Food Chem Toxicol Source Type: research

The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway.
Abstract To investigate the anti-tumor activities of WZ35 and its possible molecular mechanism, bioinformatics analysis and the hematoxylin-eosin (HE) staining were applied to evaluate the Yes-associated-protein (YAP) level in gastric cancer. Cell counting kit-8 (CCK-8) was used to examine cell viability. Apoptosis was determined by flow cytometry analysis. Seahorse bioenergetics analyzer was used to investigate the alteration of oxygen consumption and aerobic glycolysis rate. SiRNA transfection was applied to silence endogenous YAP. Western blot was performed to detect indicated proteins. We found that treatment ...
Source: Food and Chemical Toxicology - January 16, 2020 Category: Food Science Authors: Chen T, Zhao L, Chen S, Zheng B, Chen H, Zeng T, Sun H, Zhong S, Wu W, Lin X, Wang L Tags: Food Chem Toxicol Source Type: research

Upregulation of OPA1 by carnosic acid is mediated through induction of IKK γ ubiquitination by parkin and protects against neurotoxicity.
In conclusion, the mechanism by which CA counteracts the toxicity of 6-OHDA is through modulation of mitochondrial dynamics and upregulation of OPA1 via activation of the parkin/IKKγ/p65 pathway. PMID: 31705926 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - November 5, 2019 Category: Food Science Authors: Lin CY, Chen WJ, Fu RH, Tsai CW Tags: Food Chem Toxicol Source Type: research

Camptothecin induces c-Myc- and Sp1-mediated hTERT expression in LNCaP cells: Involvement of reactive oxygen species and PI3K/Akt.
Abstract Camptothecin (CPT), a quinoline alkaloid isolated from Camptotheca acuminate, targets topoisomerase I, which is continuously expressed in cancer cells. However, the molecular mechanisms responsible for CPT-induced telomerase inhibition remain unclear. Unexpectedly, we found that CPT upregulates hTERT expression and concomitantly increases telomerase activity. However, transfection of hTERT-targeting siRNA had no effect on CPT-induced G2/M phase arrest, suggesting that CPT-induced telomerase activation was not related to G2/M phase arrest. CPT simultaneously increased Nrf2 expression and the level of intra...
Source: Food and Chemical Toxicology - March 5, 2019 Category: Food Science Authors: Dilshara MG, Jayasooriya RGPT, Choi YH, Kim GY Tags: Food Chem Toxicol Source Type: research

PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells.
In conclusion, CA appears to counteract the neurotoxicity of 6-OHDA by activating PINK1/parkin-mediated mitophagy. PMID: 30707903 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - January 29, 2019 Category: Food Science Authors: Lin CY, Tsai CW Tags: Food Chem Toxicol Source Type: research

Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.
Abstract Phthalates are being suggested to be associated with altered thyroid function and proliferative changes, but detailed mechanisms remain unclear. Here, we examined the effects of di-(2-ethylhexyl) phthalate (DEHP) on DNA damage and proliferation in thyroid using thyroid carcinoma cell line, 8505C, in vitro and the rats orally treated with DEHP at 0, 0.3, 3, 30 and 150 mg/kg for 90 days from post-natal day 9 in vivo. Exposure to DHEP (1-50 μM) induced cellular proliferation, as evidenced by increased cell viability and DNA synthesis. Activation of γH2AX, a sensitive biomarker for DNA damage was observ...
Source: Food and Chemical Toxicology - December 10, 2018 Category: Food Science Authors: Kim S, Park GY, Yoo YJ, Jeong JS, Nam KT, Jee SH, Lim KM, Lee YS Tags: Food Chem Toxicol Source Type: research

Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK.
In this study, we found that CPT enhanced c-Myc expression and that the transient knockdown of c-Myc abrogated reactive oxygen species (ROS) generation, which resulted in the accumulation of ER stress-regulating proteins, such as PERK, eIF2α, ATF4, and CHOP. Moreover, the transfection of eIF2α-targeted siRNA attenuated CPT-induced autophagy and decreased the levels of Beclin-1 and Atg7, which indicated that CPT upregulated ER stress-mediated autophagy. In addition, CPT phosphorylated AMPK in response to intracellular Ca2+ release. Ca2+ chelators, ethylene glycol tetraacetic acid and a CaMKII inhibitor, K252a, decreased C...
Source: Food and Chemical Toxicology - September 25, 2018 Category: Food Science Authors: Jayasooriya RGPT, Dilshara MG, Karunarathne WAHM, Molagoda IMN, Choi YH, Kim GY Tags: Food Chem Toxicol Source Type: research

Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.
Abstract Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epi...
Source: Food and Chemical Toxicology - September 20, 2018 Category: Food Science Authors: Lang F, Qu J, Yin H, Li L, Zhi Y, Liu Y, Fang Z, Hao E Tags: Food Chem Toxicol Source Type: research

Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.
Abstract Metastasis is commonly seen in advanced stage of cancers, and matrix metalloproteinases (MMPs) are commonly up-regulated and have been identified as critical regulators. In this present study, a flavonoid, fisetin, which can be found in diverse foods, is investigated for its ability to inhibit cell motility, and the underlying mechanism is also studied in breast cancer cells (4T1 and JC cells). We have revealed that fisetin increased HO-1 mRNA and protein expressions. Besides, fisetin also elevated Nrf2 expression in nuclear fraction. By silencing Nrf2, fisetin-induced HO-1 expression was abrogated, sugge...
Source: Food and Chemical Toxicology - August 1, 2018 Category: Food Science Authors: Tsai CF, Chen JH, Chang CN, Lu DY, Chang PC, Wang SL, Yeh WL Tags: Food Chem Toxicol Source Type: research

Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
In conclusion, OXY increases NAD+ levels, resulting in the stimulation of MUC2 expression in LS 174T cells. These findings present a novel role for NAD+ in stimulation of MUC2 expression. PMID: 29935245 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - June 20, 2018 Category: Food Science Authors: Hwang D, Jo H, Ma SH, Lim YH Tags: Food Chem Toxicol Source Type: research