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Specialty: Drugs & Pharmacology
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie

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Total 256 results found since Jan 2013.

SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression
In this study, we designed and synthesized a small interfering RNA (siRNA, named siRNA-circFARSA), which specifically inhibits circFARSA expression. Using liposomes and porous silicon nanoparticles (pSiNPs) as siRNA delivery system, we prepared liposome-siRNA-circFARSA and pSiNP-PEI-siRNA-circFARSA and investigated their anti-cancer mechanism by quantitative real-time PCR and western blotting. Cell proliferation curves and transwell migration assays were performed to investigate the effect of siRNAs proliferation and migration capabilities of cancer cells. Patient-derived tumor xenograft mouse models were used to investiga...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 1, 2022 Category: Drugs & Pharmacology Authors: Huixiao Yuan Xin Huang Qingqing Li Cici Luo Chenyu Lin Shuxian Zhang Yaguang Zhang Zhilin Yan Ning Du Zhongmin Liu Hua Jiang Bingdi Chen Source Type: research

The paradigm of miRNA and siRNA influence in Oral-biome
Biomed Pharmacother. 2023 Jan 20;159:114269. doi: 10.1016/j.biopha.2023.114269. Online ahead of print.ABSTRACTShort nucleotide sequences like miRNA and siRNA have attracted a lot of interest in Oral-biome investigations. miRNA is a small class of non-coding RNA that regulates gene expression to provide effective regulation of post-transcription. On contrary, siRNA is 21-25 nucleotide dsRNA impairing gene function post-transcriptionally through inhibition of mRNA for homologous dependent gene silencing. This review highlights the application of miRNA in oral biome including oral cancer, dental implants, periodontal diseases...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2023 Category: Drugs & Pharmacology Authors: Adrija Sinha Rahul Bhattacharjee Basudha Bhattacharya Aditya Nandi Ramya Shekhar Ankit Jana Koustav Saha Lamha Kumar Swadheena Patro Pritam Kumar Panda Nagendra Kumar Kaushik Mrutyunjay Suar Suresh K Verma Source Type: research

Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line.
CONCLUSION: Our results suggest that the bach1 can be considered as a potent adjuvant in breast cancer therapy. PMID: 28092843 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 12, 2017 Category: Drugs & Pharmacology Authors: Aletaha M, Mansoori B, Mohammadi A, Fazeli M, Baradaran B Tags: Biomed Pharmacother Source Type: research

BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
CONCLUSION: Our results indicated that BACH1 down-regulation in HT29 CRC cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression. Collectively, these results suggest that BACH1 may function as an oncogenic driver in colon cancer and may represent as a potential target of gene therapy for CRC treatment. PMID: 27657827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Davudian S, Shajari N, Kazemi T, Mansoori B, Salehi S, Mohammadi A, Shanehbandi D, Shahgoli VK, Asadi M, Baradaran B Tags: Biomed Pharmacother Source Type: research

Mirror siRNAs loading for dual delivery of doxorubicin and autophagy regulation siRNA for multidrug reversing chemotherapy.
Abstract The multidrug resistance (MDR) which widely observed in multiple cancer types is responsible for the poor chemotherapy benefits of doxorubicin (Dox). Here in our study, Dox was firstly loaded into a scramble siRNA and then condensed by polyethyleneimine (PEI) 25k together with anti-autophagy siRNA, the obtained PEI/Si-D containing mirror RNAs was further coated with hyaluronic acid (HA) to shield the surface charge of PEI and offer tumor-homing property that finally developed a platform for effective cancer chemotherapy (HP/Si-D). Our results revealed that the obtained HP/Si-D was showed high stability an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 22, 2020 Category: Drugs & Pharmacology Authors: Yang B, Hao A, Chen L Tags: Biomed Pharmacother Source Type: research

Reversal of chemoresistance with small interference RNA (siRNA) in etoposide resistant acute myeloid leukemia cells (HL-60).
CONCLUSIONS: Our results indicate that product of the ABCB1 gene have effective role in resistance to etoposide in acute myeloid leukemia cells. PMID: 26463638 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2015 Category: Drugs & Pharmacology Authors: Kachalaki S, Baradaran B, Majidi J, Yousefi M, Shanehbandi D, Mohammadinejad S, Mansoori B Tags: Biomed Pharmacother Source Type: research

Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).
Abstract Non-small cell lung cancer (NSCLC) is a common diagnosed cancer disease worldwide and its management remains a challenge. Synergistic cancer therapeutic strategy is interesting for multiple advantages, such as excellent targeting accuracy, low side effects, and promoted therapeutic efficiency. In the present study, myricetin (Myr)-loaded mesoporous silica nanoparticles (MSN) combined with multidrug resistance protein (MRP-1) siRNA was prepared. The surface of the synthesized nanoparticles was modified with folic acid (FA) to promote the therapeutic efficiency of Myr for the treatment of NSCLC. The collect...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 21, 2020 Category: Drugs & Pharmacology Authors: Song Y, Zhou B, Du X, Wang Y, Zhang J, Ai Y, Xia Z, Zhao G Tags: Biomed Pharmacother Source Type: research

Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator-induced lung injury
In this study, VILI was generated in mice with high tidal volume mechanical ventilation (20 ml/kg). Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 concentrations in serum and gut measured by ELISA showed significant elevation in the VILI mice. Significant increases in gut injury and PANoptosis were observed in the VILI mice, which were positively correlated with the serum levels of TNF-α, IL-1β, and IL-6. The VILI mice displayed intestinal barrier defects, decreased expressions of occludin and zonula occludin-1 (ZO-1), and increased expression of claudin-2 and the activation of myosin light chain (...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 29, 2023 Category: Drugs & Pharmacology Authors: Ning Ding Hui Xiao Lixiao Zhen Huiqing Li Zengzhen Zhang Junke Ge Haiyan Jia Source Type: research

Effect of notch1,2,3 genes silicing on NF- κB signaling pathway of macrophages in patients with atherosclerosis.
CONCLUSIONS: There was a positive regulation between Notch and NF-κB signaling pathway in patients with AS. Notch1 may play a more important role than notch2 and notch 3 in the regulation of NF-κB signaling pathway in AS. PMID: 27697639 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 29, 2016 Category: Drugs & Pharmacology Authors: Ruan ZB, Fu XL, Li W, Ye J, Wang RZ, Zhu L Tags: Biomed Pharmacother Source Type: research

Role of high mobility group A1/nuclear factor-kappa B signaling in coronary microembolization-induced myocardial injury.
CONCLUSIONS: HMGA1/NF-κB signaling is involved in CME-induced myocardial inflammation. Inhibition of HMGA1/NF-κB signaling attenuated the CME-induced myocardial injury and improved cardiac function, suggesting a new potential target for the prevention and treatment of CME-induced myocardial injury. PMID: 30021353 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 21, 2018 Category: Drugs & Pharmacology Authors: Su Q, Lv X, Sun Y, Yang H, Ye Z, Li L Tags: Biomed Pharmacother Source Type: research

The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Abstract The purpose of this study was to explore the role by which the DNA-dependent protein kinase complex catalytic subunit (DNA-PKcs) influences osteosarcoma MG-63 cell apoptosis, proliferation, migration and invasion. Osteosarcoma tissues and adjacent normal tissues were obtained from 57 osteosarcoma patients. Human osteosarcoma MG-63 cells were assigned into designated groups including the blank, siRNA-negative control (NC) and siRNA-DNA-PKcs groups. RT-qPCR and Western blotting methods were employed to evaluate the mRNA and protein expressions of DNA-PKcs. A cell counting kit-8 (CCK-8) assay was performed t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2017 Category: Drugs & Pharmacology Authors: Jin PY, Lu HJ, Tang Y, Fan SH, Zhang ZF, Wang Y, Li XN, Wu DM, Lu J, Zheng YL Tags: Biomed Pharmacother Source Type: research