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Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children
Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) pandemic, global sequencing efforts have led in the field of inborn errors of immunity, and inspired particularly by previous research on life-threatening influenza, they have revealed that known and novel inborn errors affecting type I interferon immunity underlie critical COVID-19 in up to 5% of cases. In addition, neutralizing autoantibodies against type I interferons have been identified in up to 20% of patients with critical COVID-19 who are older than 80 years and 20% of fatal cases, with a high...
Source: Journal of Allergy and Clinical Immunology - February 23, 2023 Category: Allergy & Immunology Authors: Giorgia Bucciol, COVID Human Genetic Effort, Isabelle Meyts Source Type: research

Regulatory T Cells are Necessary for Generation of CD8+ Tissue Resident Memory T cells Following Influenza Infection
Respiratory viral infections such as influenza are an important cause of morbidity and mortality. Understanding the immune mechanisms behind generation of protective memory responses is valuable in discovering potential therapies. The aim of our study was to determine whether regulatory T cells (Treg) promote the generation of CD8+ tissue resident memory T cells (Trm) following influenza infection in mice.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Nurbek Mambetsariev, Manuel Torres Acosta, Benjamin Singer Source Type: research

Survey of Influenza/Covid-19 Vaccination of High risk Brooklyn Residents
To learn more about inner-city high-risk patients' knowledge and attitudes regarding influenza and Covid-19 vaccines.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Jodan Pathinathan, Shella Steinberg, Alexander Babazadeh, Mariam Majzoub, Venkatesh Sabhae Gangadharappa, Rauno Joks Source Type: research

Influenza vaccination patterns in an Allergy specialty clinic during COVID-19
We sought to determine the effect of the SARS-COV-2 pandemic on seasonal influenza vaccine patterns in a tertiary care, pediatric Allergy clinic.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Jackson Massanelli, Robbie Pesek, Amika Sood, Kim Cobb, Stacie Jones Source Type: research

Impact of Age and Region on Immune Responses to Allergy Immunotherapy
Allergy immunotherapy (AIT) can prevent allergic disease by modifying the adaptive immune system, similar to anti-pathogen vaccines, supporting the concept of AIT as an “allergy vaccination”. Some vaccines, e.g. influenza, pneumococcal pneumoniae, are administered globally with the same dose for all age groups. The aim of this study was to determine if sublingual immunotherapy (SLIT) across regions and age groups induce similar immunologic changes in IgE and Ig G4 with the goal of using the same dose and formulation worldwide.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Josephine Nolte Peterlin, Vibeke Backer, Thomas Stranzl, Veronica Hulstroem, Peter Sejer Andersen, Hendrik Nolte Source Type: research

Improving Influenza Immunization Rates
Influenza virus is an important cause of respiratory disease during the winter months. This past flu season, our objective was to ensure =>80% of eligible patients seen in our clinic were up to date for the influenza vaccine by 1Dec2019.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jun Mendoza, James Quinn Source Type: research

Influenza Vaccination of High Risk Brooklyn Residents Questionnaire
To learn more about inner-city high-risk patients ’ knowledge and attitudes regarding influenza and influenza vaccine.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Venkatesh Sabhae Gangadharappa, Rauno Joks Source Type: research

A Quality Improvement Initiative to Improve Resident- Physician Practices Regarding Flu Vaccine Administration in Individuals with Egg Allergy
Individuals with any severity of egg allergy, including anaphylaxis, should receive the influenza vaccine annually per CDC guidelines. This recommendation has evolved over the past ten years. We performed a quality improvement initiative to assess and improve resident physician practices regarding flu vaccine administration in egg allergic individuals.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Aishwarya Navalpakam, Shweta Saini, Chi- Lan Tran, Jenny Huang, Divya Seth, Pavadee Poowuttikul Source Type: research

RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness
Suppression of both RIG-I and TLR4-mediated immune responses is common in previously immunocompetent children with critical influenza and is associated with worse clinical outcomes than suppression of either pathway alone.
Source: Journal of Allergy and Clinical Immunology - February 4, 2020 Category: Allergy & Immunology Authors: Tanya Novak, Mark W. Hall, Douglas R. McDonald, Margaret M. Newhams, Anushay J. Mistry, Angela Panoskaltsis-Mortari, Peter M. Mourani, Laura L. Loftis, Scott L. Weiss, Keiko M. Tarquinio, Barry Markovitz, Mary E. Hartman, Adam Schwarz, Wolfgang G. Junger, Source Type: research

A computable phenotype for influenza vaccination status in patients with asthma
Upper respiratory infections are associated with up to 80% of asthma exacerbations. Investigating the role of influenza vaccination on asthma exacerbations using electronic health records (EHRs) is challenging due to lack of a computable phenotype for influenza vaccination. The purpose of this project was to develop an influenza vaccination computable phenotype, and evaluate its performance against manual chart review.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Edwin Dovigi, Rafsa Khan, Pankaja Desai, Raj Shah, Ekta Kishen, Christopher Codispoti Source Type: research

Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma
Live attenuated influenza vaccine (LAIV) is recommended for annual influenza vaccination in children from age 2 years. However, some guidelines recommend against its use in children with asthma or recurrent wheeze due to concerns over its potential to induce wheezing.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research

Safety of Live Attenuated Influenza Vaccine in Children with Moderate-Severe Asthma
In a phase IV, multicenter prospective cohort study of 478 children with asthma, LAIV did not cause a significant change in asthma control, including in preschool children and young people with poorly controlled or difficult asthma.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research

Impaired control of multiple viral infections in a family with complete IRF9 deficiency
Interferon regulatory factor (IRF) 9 contributes to IFN- αβ–induced gene expression by binding interferon-stimulated response element sequences located in the promoters of interferon-stimulated genes (ISGs),1 whereas a C-terminal IRF association domain mediates interactions with signal transducer and activator of transcription (STAT) 1 and STAT2 to in crease ISG transcription.2,3 Recently, a child who presented with a severe respiratory tract infection caused by influenza A was identified as IRF9 deficient because of a c.991G>A mutation in IRF9 that led to skipping of exon 7 and a shortened IRF9 protein with reduced function.
Source: Journal of Allergy and Clinical Immunology - February 28, 2019 Category: Allergy & Immunology Authors: Mar ía Bravo García-Morato, Ane Calvo Apalategi, Luz Yadira Bravo-Gallego, Alfonso Blázquez Moreno, Miriam Simón-Fuentes, Jenny V. Garmendia, Ana Méndez Echevarría, Teresa del Rosal Rabes, Ángeles Domínguez-Soto, Eduardo López-Granados, Hugh T. R Tags: Letters to the editor Source Type: research

Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy
Mining of social media data suggests that skin and soft tissue infection from allergen immunotherapy, prepared with aseptic technique, is as rare as skin and soft tissue infection from Influenza vaccination, a sterile pharmaceutical.
Source: Journal of Allergy and Clinical Immunology - February 2, 2019 Category: Allergy & Immunology Authors: Kimberly G. Blumenthal, Maxim Topaz, Li Zhou, Tyler Harkness, Roee Sa ’adon, Ofrit Bar-Bachar, Aidan A. Long Source Type: research

Can Obesity Alter the Immune Response to Childhood Vaccinations?
Obesity is a major health issue in children. It is associated with increased risk of infections and infectious morbidity. Previous studies found a decrease in protective antibody titers to hepatitis B and influenza in obese adults after vaccination. Less is known about antibody responses to routine childhood immunization in obese children.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Jenny Y. Huang, Bani Preet Kaur, Divya Seth, Milind V. Pansare, Deepak Kamat, Eric McGrath, Elizabeth A. Secord, Pavadee Poowuttikul Source Type: research

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