RIG-I and TLR4 Responses and Adverse Outcomes in Pediatric Influenza-Related Critical Illness

Suppression of both RIG-I and TLR4-mediated immune responses is common in previously immunocompetent children with critical influenza and is associated with worse clinical outcomes than suppression of either pathway alone.

Source: Journal of Allergy and Clinical Immunology - February 4, 2020 Category: Allergy & Immunology Authors: Tanya Novak, Mark W. Hall, Douglas R. McDonald, Margaret M. Newhams, Anushay J. Mistry, Angela Panoskaltsis-Mortari, Peter M. Mourani, Laura L. Loftis, Scott L. Weiss, Keiko M. Tarquinio, Barry Markovitz, Mary E. Hartman, Adam Schwarz, Wolfgang G. Junger, Source Type: research