Filtered By:
Source: Breast Cancer Research and Treatment

This page shows you your search results in order of date.

Order by Relevance | Date

Total 20 results found since Jan 2013.

KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence
ConclusionThe data demonstrates that KIF21A is an important regulator of breast cancer aggressiveness and may be useful in refining prognostication of this malignant disease.
Source: Breast Cancer Research and Treatment - October 26, 2021 Category: Cancer & Oncology Source Type: research

KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer
ConclusionWe conclude that KMT2C could serve as a potential biomarker of prognosis and chemotherapy sensitivity by affecting the DNA damage repair-related genes of breast cancer.
Source: Breast Cancer Research and Treatment - July 8, 2021 Category: Cancer & Oncology Source Type: research

The epithelial sodium channel has a role in breast cancer cell proliferation
ConclusionαENaC expression is associated with a poor prognosis in breast cancer and is a novel regulator of breast cancer cell proliferation. Taken together, these results identify ENaC as a potential future therapeutic target.
Source: Breast Cancer Research and Treatment - February 25, 2021 Category: Cancer & Oncology Source Type: research

Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration
ConclusionPGRN/GP88 represents a therapeutic target with companion diagnostics. Blocking PGRN/GP88 with antibody treatment may  provide novel-targeted solutions in TNBC treatment which could eventually address the issue of toxicity and unresponsiveness associated with SOC.
Source: Breast Cancer Research and Treatment - February 22, 2021 Category: Cancer & Oncology Source Type: research

Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer
ConclusionsER β2/ERβ5 and ERβ1 exhibit sharply contrasting activities in TNBC cells. Our findings imply that delineating the absolute amounts and relative ratios of the different ERβ isoforms might have prognostic and therapeutic relevance, and could enable better selection of optimal approaches for treatment of this often aggressive form of breast cancer.
Source: Breast Cancer Research and Treatment - September 30, 2020 Category: Cancer & Oncology Source Type: research

Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer
ConclusionsmTOR signaling is highly activated in TNBC tumors. As single rapalog treatment is insufficient to block mTOR signaling in rapalog-resistant TNBC cells, our results thus provide a potential multi-kinase inhibitor combinatorial strategy to overcome mTOR-targeted therapy resistance in TNBC cells.
Source: Breast Cancer Research and Treatment - October 17, 2019 Category: Cancer & Oncology Source Type: research

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype
ConclusionsThe sensitivity of BT-549 and Hs578T cells to englerin A and digoxin suggests a subset of TNBCs are highly susceptible to cation disruption and encourages investigation of TRPC1 and TRPC4 as potential new biomarkers of sensitivity to cardiac glycosides.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78
ConclusionOur study warrants IKM5, a potential anticancer agent that can abrogate invasion and metastasis, suggesting its clinical development for the treatment of patients with advanced breast cancer.
Source: Breast Cancer Research and Treatment - July 27, 2019 Category: Cancer & Oncology Source Type: research

FOXM1 transcriptionally regulates expression of integrin β1 in triple-negative breast cancer
ConclusionOur study suggests that FOXM1 transcription factor regulates Integrin β1 gene expression and that FOXM1/ Integrin-β1/FAK axis may play an important role in the progression of TNBC.
Source: Breast Cancer Research and Treatment - May 11, 2017 Category: Cancer & Oncology Source Type: research

Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention
Abstract Curcumin is a potential agent for both the prevention and treatment of cancers. Curcumin treatment alone, or in combination with piperine, limits breast stem cell self-renewal, while remaining non-toxic to normal differentiated cells. We paired fluorescence-activated cell sorting with RNA sequencing to characterize the genome-wide changes induced specifically in normal breast stem cells following treatment with these compounds. We generated genome-wide maps of the transcriptional changes that occur in epithelial-like (ALDH+) and mesenchymal-like (ALDH−/CD44+/CD24−) normal breast stem/progenitor cells ...
Source: Breast Cancer Research and Treatment - June 14, 2016 Category: Cancer & Oncology Source Type: research

Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells
Abstract Metformin, which is a drug commonly prescribed to treat type 2 diabetes, has anti-proliferative effects in cancer cells; however, the molecular mechanisms underlying this effect remain largely unknown. The aim is to investigate the role of tristetraprolin (TTP), an AU-rich element-binding protein, in anti-proliferative effects of metformin in cancer cells. p53 wild-type and p53 mutant breast cancer cells were treated with metformin, and expression of TTP and c-Myc was analyzed by semi-quantitative RT-PCR, Western blots, and promoter activity assay. Breast cancer cells were transfected with siRNA against T...
Source: Breast Cancer Research and Treatment - March 8, 2016 Category: Cancer & Oncology Source Type: research

High-density lipoprotein of patients with breast cancer complicated with type 2 diabetes mellitus promotes cancer cells adhesion to vascular endothelium via ICAM-1 and VCAM-1 upregulation
Abstract Adhesion of disseminating tumor cells to vascular endothelium is a pivotal starting point in the metastasis cascade. We have shown previously that diabetic high-density lipoprotein (HDL) has the capability of promoting breast cancer metastasis, and this report summarizes our more recent work studying the role of abnormal HDL in facilitating the adhesion of the circulating tumor cells to the endothelium. This is an initiating step in breast cancer metastasis, and this work assesses the role of ICAM-1 and VCAM-1 in this process. MDA-MB-231, MCF 7, and human umbilical vein endothelial cells (HUVECs) were tre...
Source: Breast Cancer Research and Treatment - February 12, 2016 Category: Cancer & Oncology Source Type: research

Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro
Abstract Toll-like receptor 9 (TLR9) is a cellular DNA-receptor widely expressed in cancers. We previously showed that synthetic and self-derived DNA fragments induce TLR9-mediated breast cancer cell invasion in vitro. We investigated here the invasive effects of two nuclease-resistant DNA fragments, a 9-mer hairpin, and a G-quadruplex DNA based on the human telomere sequence, both having native phosphodiester backbone. Cellular uptake of DNAs was investigated with immunofluorescence, invasion was studied with Matrigel-assays, and mRNA and protein expression were studied with qPCR and Western blotting and prot...
Source: Breast Cancer Research and Treatment - January 18, 2016 Category: Cancer & Oncology Source Type: research

Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na + /K + -ATPase and cell survival
We examined if such overexpression might protect Na+/K+-ATPase and cancer cells against the high levels of oxidative stress characteristic of many tumors and often induced by cancer treatments. We measured FXYD3 expression, Na+/K+-ATPase activity and glutathionylation of the β1 subunit of Na+/K+-ATPase, a reversible oxidative modification that inhibits the ATPase, in MCF-7 and MDA-MB-468 cells. Expression of FXYD3 was suppressed by transfection with FXYD3 siRNA. A colorimetric end-point assay was used to estimate cell viability. Apoptosis was estimated by caspase 3/7 (DEVDase) activation using a Caspase fluorogenic substr...
Source: Breast Cancer Research and Treatment - January 6, 2016 Category: Cancer & Oncology Source Type: research

Gene expression alterations associated with outcome in aromatase inhibitor-treated ER+ early-stage breast cancer patients
Abstract Aromatase inhibitors (AI), either alone or together with chemotherapy, have become the standard adjuvant treatment for postmenopausal, estrogen receptor-positive (ER+) breast cancer. Although AIs improve overall survival, resistance is still a major clinical problem, thus additional biomarkers predictive of outcome of ER+ breast cancer patients treated with AIs are needed. Global gene expression analysis was performed on ER+ primary breast cancers from patients treated with adjuvant AI monotherapy; half experienced recurrence (median follow-up 6.7 years). Gene expression alterations were validated by qR...
Source: Breast Cancer Research and Treatment - November 19, 2015 Category: Cancer & Oncology Source Type: research