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Source: BMC Cancer

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Total 95 results found since Jan 2013.

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
Conclusions: Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.
Source: BMC Cancer - December 5, 2013 Category: Cancer & Oncology Authors: Maximilian LinxweilerStefan SchorrNico SchäubleMartin JungJohannes LinxweilerFrank LangerHans-Joachim SchäfersAdolfo CavaliéRichard ZimmermannMarkus Greiner Source Type: research

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
Conclusions: These observations imply that the frequently noted loss-of-function of NKX3.1 cooperates with the activation of TMPRSS2-ERG fusions in prostate tumorigenesis.
Source: BMC Cancer - January 13, 2014 Category: Cancer & Oncology Authors: Rajesh ThangapazhamFrancisco SaenzShilpa KattaAhmed MohamedShyh-Han TanGyorgy PetrovicsShiv SrivastavaAlbert Dobi Source Type: research

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
Conclusions: These results suggest that the synergy between PMA and apicularen A is involved by PKCalpha activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.
Source: BMC Cancer - January 22, 2014 Category: Cancer & Oncology Authors: Kang-Sik SeoJong-Seok KimJi-Hoon ParkKyoung-Sub SongEun-Jin YunJong-Il ParkGi Ryang KweonWan-Hee YoonKyu LimByung-Doo Hwang Source Type: research

The novel IGF-IR/Akt¿dependent anticancer activities of glucosamine
Conclusions: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer.
Source: BMC Cancer - January 20, 2014 Category: Cancer & Oncology Authors: Ki-Hoon SongJu-Hee KangJong-Kyu WooJeong-Seok NamHye-Young MinHo-Young LeeSoo-Youl KimSeung-Hyun Oh Source Type: research

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells
Conclusions: Findings reported herein uncover a mechanism for the anti-tumor activity of metformin in prostate cancer, which is independent of its anti-diabetic effects. These data provide a rationale for the use of metformin in the treatment of hormone naive and castration-resistant prostate cancer and suggest AR is an important indirect target of metformin.
Source: BMC Cancer - January 31, 2014 Category: Cancer & Oncology Authors: Ummuhan DemirAndrea KoehlerRainer SchneiderSusann SchweigerHelmut Klocker Source Type: research

FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer
Conclusions: These results suggest that FOXA1 promotes cell proliferation by AR and activates Notch pathway. It indicated that FOXA1 and AR may serve as potential gene therapy in EC.
Source: BMC Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Meiting QiuWei BaoJingyun WangTingting YangXiaoying HeYun LiaoXiaoping Wan Source Type: research

PKC alpha regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer
Conclusions: The present study identified netrin-1/UNC5B, which could be regulated by PKC signaling, was important mediators of bladder cancer progression.
Source: BMC Cancer - February 15, 2014 Category: Cancer & Oncology Authors: Jiao LiuChui-ze KongDa-xin GongZhe ZhangYu-yan Zhu Source Type: research

Increased paired box transcription factor 8 has a survival function in Glioma
Conclusions: PAX8 is increased in the majority of glioblastomas and promoted cell survival. Because PAX8 is absent in normal brain tissue, it may be a promising therapeutic target pathway for treating aggressive gliomas.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Noelyn HungYu-Jen ChenAhmad TahaMagnus OlivecronaRonald BoetAnna WilesTracy WarrAlisha ShawRamona EiholzerBruce BaguleyMichael EcclesAntony BraithwaiteMartin MacFarlaneJanice RoydsTania Slatter Source Type: research

Role of Pax8 in the regulation of MET and RON receptor Tyrosine Kinases in non-small cell lung cancer
Conclusion: PAX8 provides signals for growth and motility of NSCLC cells and is necessary for MET and RON expression. Further investigations are necessary to investigate the therapeutic potential of PA8 in NSCLC.
Source: BMC Cancer - March 14, 2014 Category: Cancer & Oncology Authors: Rajani KantetiEssam El-HashaniImmanuel DhanasinghMaria TretiakovaAliya HusainSherven SharmaJay SharmaEverett VokesRavi Salgia Source Type: research

MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression
Conclusions: These findings indicate that MUC16 protects EOC cells against TRAIL-induced apoptosis through multiple mechanisms including the blockade of TRAIL R2 expression and the regulation of cFLIP expression at both the transcriptional and the protein level.
Source: BMC Cancer - April 1, 2014 Category: Cancer & Oncology Authors: Isabelle MatteDenis LaneMarianne BoivinClaudine RancourtAlain Piché Source Type: research

Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of alphaB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of alphaB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Effect of hypoxia on the expression of ¿B-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of αB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of αB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation
Conclusions: Our data indicate that enhanced EGFR-driven signalling is sufficient to overrule the TAM- mediated inhibition of E2-driven cell proliferation. This may have profound implications for the anti-estrogen treatment of ER-positive breast cancers that have increased levels of EGFR.
Source: BMC Cancer - April 23, 2014 Category: Cancer & Oncology Authors: Marja MoerkensYinghui ZhangLynn WesterBob van de WaterJohn Meerman Source Type: research

Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors
Conclusion: Taken together, our findings show that MMP-10 can play a significant role in tumor growth and progression, and that MMP-10 perturbation may represent a rational strategy for cancer treatment.
Source: BMC Cancer - May 3, 2014 Category: Cancer & Oncology Authors: Ge ZhangMakito MiyakeAdrienne LawtonSteve GoodisonCharles Rosser Source Type: research

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway
Conclusion: VPA enhances the susceptibility of pancreatic cancer cells to NK cell-mediated cytotoxicity both in vitro and in vivo by upregulating the expression of MICA and MICB via a PI3K/Akt signaling pathway-dependent mechanism.
Source: BMC Cancer - May 25, 2014 Category: Cancer & Oncology Authors: Pengfei ShiTao YinFeng ZhouPengfei CuiShanmiao GouChunyou Wang Source Type: research