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Effect of anti-M üllerian hormone on the regulation of pituitary gonadotropin subunit expression: roles of kisspeptin and its receptors in gonadotroph LβT2 cells
In this study, we examined the effect of AMH on pituitary gonadotrophs. We detected AMH and AMH receptor type 2 expression in LβT2 cells. In these cells, the expression of FSHβ- but not α- and LHβ-subunits increased significantly as the concentration of AMH increased. LβT2 cells expressed Kiss-1 and Kiss-1R. AMH stimulation resulted in decreases in both Kiss-1 and Kiss-1R. The siRNA-mediated knockdown of Kiss-1 in LβT2 cells did not alter the basal expression levels of α-, LHβ-, and FSHβ-subunits. In LβT2 cells overexpressing Kiss-1R, exogenous kisspeptin stimulation significantly increased the expression of all ...
Source: Endocrine Journal - May 17, 2021 Category: Endocrinology Authors: Tuvshintugs Tumurbaatar Haruhiko Kanasaki Zolzaya Tumurgan Aki Oride Hiroe Okada Satoru Kyo Source Type: research

Mass Spectrometry Imaging Identifies Metabolic Patterns Associated with Malignant Potential in Pheochromocytoma and Paraganglioma
CONCLUSIONS: The present study has identified distinct tissue metabolomic profiles of PPGLs in relation to tumor genotypes. In addition, we revealed significantly altered metabolites in the kynurenine pathway in metastatic PPGLs, which can aid in the prediction of its malignant potential. However, further validation studies will be required to confirm our findings.PMID:33983135 | DOI:10.1530/EJE-20-1407
Source: European Journal of Endocrinology - May 13, 2021 Category: Endocrinology Authors: Masanori Murakami Na Sun Christian Greunke Annette Feuchtinger Stefan Kircher Timo Deutschbein Thomas Papathomas Nicole Bechmann Paal William Wallace Mirko Peitzsch Esther Korpershoek Juliane Friemel Anne Paule Gimenez Roqueplo Mercedes Robledo Henri Jlm Source Type: research

Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells
Conclusions. Results of this investigation demonstrated that silencing of HSPB8 mRNA affected the expression of IRS1 gene as well as many other genes encoding tumor growth related proteins. It is possible that the dysregulation of most of the studied genes in glioma cells after silencing of HSPB8 is reflected by a complex of intergenic interactions and that this polyfunctional chaperone is an important factor for the stability of genome function and regulatory mechanisms contributing to the tumorigenesis control.PMID:33885248 | DOI:10.2478/enr-2020-0026
Source: Endocrine Regulations - April 22, 2021 Category: Endocrinology Authors: Oksana S Hnatiuk Dariia O Tsymbal Dmytro O Minchenko Olena O Khita Yulia M Viletska Olha V Rundytska Halyna E Kozynkevych Hanna S Maslak Oleksandr H Minchenko Source Type: research

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