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The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice
Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

What Causes Vomiting?
Discussion Regurgitation is a passive expulsion of ingested material out of the mouth. It is a normal part of digestion for ruminants such as cows and camels. Nausea is an unpleasant abdominal perception that the person may describe as feeling ill to the stomach, or feeling like he/she is going to vomit. Anorexia is frequently observed. Nausea is usually associated with decreased stomach activity and motility in the small intestine. Parasympathetic activity may be increased causing pale skin, sweating, hypersalivation and possible vasovagal syndrome (hypotension and bradycardia). Retching or dry heaves is when there are sp...
Source: PediatricEducation.org - May 2, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Incidence and Management of Rash in Telaprevir-Treated Patients: Lessons for Simeprevir?
CONCLUSIONS: ABW and BMI appear to be related to rash development. This finding may have implications in the treatment of HCV with simeprevir, given its similarity to telaprevir. PMID: 24939632 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - June 17, 2014 Category: Drugs & Pharmacology Authors: Smith MA, Johnson HJ, Chopra KB, Dunn MA, Ulrich AM, Mohammad RA Tags: Ann Pharmacother Source Type: research