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Melatonin reverses the oxidative stress and mitochondrial dysfunction caused by LETM1 silencing.
This article is protected by copyright. All rights reserved. PMID: 31777134 [PubMed - as supplied by publisher]
Source: Cell Biology International - November 26, 2019 Category: Cytology Authors: Aral C, Demirkesen S, Bircan R, Yasar Sirin D Tags: Cell Biol Int Source Type: research

Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 6, 2021 Category: Cytology Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research

Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation
J Pineal Res. 2021 Nov 26:e12781. doi: 10.1111/jpi.12781. Online ahead of print.ABSTRACTMelatonin, secreted by the pineal gland, regulates the circadian rhythms and also plays an oncostatic roles in cancer cells. Previously, we showed that melatonin induced the expression of Bim, a pro-apoptotic Bcl-2 protein, at both the transcriptional and post-translational levels. In the present study, we investigated the molecular mechanisms underlying the melatonin-mediated Bim upregulation through post-translational regulation. We found that ovarian tumor domain-containing protein 1 (OTUD1), a deubiquitinase belonging to the OTU pro...
Source: Cell Research - November 26, 2021 Category: Cytology Authors: Seon Min Woo Seung Un Seo Kyoung-Jin Min Taeg Kyu Kwon Source Type: research