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Drug: Magnesium

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Total 10577 results found since Jan 2013.

In vivo comparison of the degradation and osteointegration properties of micro-arc oxidation-coated Mg-Sr and Mg-Ca alloy scaffolds
Biomed Mater Eng. 2021 Nov 2. doi: 10.3233/BME-211300. Online ahead of print.ABSTRACTBACKGROUND: Magnesium (Mg) alloy have biodegradation and mechanical properties that are similar to those of human bone, making it a promising candidate material for inclusion in implantable medical devices.OBJECTIVE: The osteointegration effect of Mg alloy scaffolds with different corrosion rates were studied and evaluated in large bone defect models.METHOD: Mg-Sr and Mg-Ca alloy scaffolds with a 20-μm Micro-arc oxidation (MAO) coating were used to repair critical bone defects for subsequent assessment of each alloy's degradation and oste...
Source: Bio-Medical Materials and Engineering - November 8, 2021 Category: Materials Science Authors: Hongyu Sun Yuefei Wang Chu Sun Haiming Yu Zheng Xi Na Liu Nan Zhang Source Type: research

IJERPH, Vol. 19, Pages 16006: Potential Health Risks of Lead Exposure from Early Life through Later Life: Implications for Public Health Education
khola Lead (Pb) exposure has been a serious environmental and public health problem throughout the world over the years. The major sources of lead in the past were paint and gasoline before they were phased out due to its toxicity. Meanwhile, people continue to be exposed to lead from time to time through many other sources such as water, food, soil and air. Lead exposure from these sources could have detrimental effects on human health, especially in children. UNICEF reported that approximately 800 million children have blood lead levels (BLLs) at or above 5 micrograms per deciliter (µg/dL) globally. Thi...
Source: International Journal of Environmental Research and Public Health - November 30, 2022 Category: Environmental Health Authors: Adejoke Christianah Olufemi Andile Mji Murembiwa Stanley Mukhola Tags: Brief Report Source Type: research

An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical use
This study developed an enhanced phenomenological model for the predictions of surface-based localised corrosion of magnesium alloys for use in medical applications. The modelling framework extended previous surface-based approaches by considering the role of β-phase components throughout the material volume to better predict spatial and temporal aspects of surface-based corrosion in magnesium alloys. This enhanced surface-based corrosion model offers many advantages as it (i) captures multi-directional pitting, (ii) captures various pit morphologies, (iii) eliminates mesh sizing effects, (iv) reduces computational cost t...
Source: Journal of the Mechanical Behavior of Biomedical Materials - January 7, 2023 Category: Materials Science Authors: Conall Quinn Kerstin Van Gaalen Peter E McHugh Alexander Kopp Ted J Vaughan Source Type: research

Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20;41(4):475-482. doi: 10.12122/j.issn.1673-4254.2021.04.01.ABSTRACTOBJECTIVE: The investigate the inhibitory effects of the traditional Chinese medicine (TCM) monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza Polyphenolate Injection (ZDDY) against SARS-CoV-2 infection in vitro and explore the molecular mechanism.OBJECTIVE: The anti-SARS-CoV-2 activity of Sal-B and ZDDY was assessed using the authentic and pseudotyped SARS-CoV-2 infection assay. The antiviral targets of Sal-B were identified by molecular docking and molecular dynamics simulation. Circular ...
Source: Journal of Southern Medical University - May 8, 2021 Category: Universities & Medical Training Authors: C Yang C Cheng J Wang K Chen J Zhan X Pan X Xu W Xu S Liu Source Type: research