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Advances in the Treatment of Thyroid Eye Disease Associated Extraocular Muscle Myopathy and Optic Neuropathy
AbstractPurpose of ReviewTo review emerging treatments for thyroid eye disease (TED) associated extraocular muscle myopathy and dysthyroid optic neuropathy (DON).Recent FindingsEmerging targeted biologic therapies may alter the disease course in TED. Teprotumumab, a type I insulin-like growth factor receptor inhibitor, is the most recent addition to the treatments available for TED-associated extraocular muscle myopathy causing diplopia. Small studies also suggest a potential therapeutic benefit for DON. Various recent studies have also expanded our knowledge on conventional TED therapies.SummaryThe therapeutic landscape o...
Source: Current Neurology and Neuroscience Reports - May 26, 2022 Category: Neuroscience Source Type: research

Mitochondrial dysfunction in human skeletal muscle biopsies of lipid storage disorder
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 9, 2018 Category: Neuroscience Authors: B. Debashree, Manish Kumar, T.S. Keshava Prasad, Archana Natarajan, Rita Christopher, A. Nalini, P.S. Bindu, N. Gayathri, M.M. Srinivas Bharath Tags: Original Article Source Type: research

O78 Membrane depolarization in motor nerves of critical ill patients is related to insulin resistance
Critical illness polyneuropathy/myopathy (CIP/CIM) features depolarization of the resting membrane potential and reduced membrane excitability in motor nerve and muscle.1 –3 Since CIP/CIM shows an increased Insulin resistance,4 and Insulin is one agonist of the Na-K-pump controlling resting membrane potential,5 we like to prove if Insulin resistance is correlated with motor nerve resting membrane polarisation in critical ill patients.
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Susanne Koch, Tobias Wollersheim, Kurt Mai, Kurt Haas, Claudia Spies, Steffen Weber-Carstens Source Type: research