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Effect of extracorporeal membrane oxygenation on pharmacokinetics of antimicrobial drugs: recent progress and recommendations
Nan Fang Yi Ke Da Xue Xue Bao. 2021 May 20;41(5):793-800. doi: 10.12122/j.issn.1673-4254.2021.05.23.ABSTRACTExtracorporeal membrane oxygenation (ECMO) is an effective means to provide life support for patients with severe respiratory or heart failure. Existing studies have shown that ECMO may affect the metabolic process of some drugs by drug adsorption, increasing the apparent distribution volume and changing the clearance rate of the drugs. This review summarizes the recent progress in the studies of the effect of ECMO on the pharmacokinetics of antibacterial and antifungal drugs. For the antibacterial drugs, it is recom...
Source: Journal of Southern Medical University - June 17, 2021 Category: Universities & Medical Training Authors: Y Zhang Z Zeng Q Zhang Q Ou Z Chen Source Type: research

Increasingly limited options for the treatment of enteric fever in travellers returning to England, 2014-2019: a cross-sectional analytical study
Conclusion. Third-generation cephalosporins and azithromycin remain appropriate choices for empirical treatment of enteric fever in most returning travellers to the UK from endemic countries, except from Pakistan, where XDR represents a significant risk.PMID:34351258 | DOI:10.1099/jmm.0.001359
Source: Journal of Medical Microbiology - August 5, 2021 Category: Microbiology Authors: M Trent Herdman Basel Karo Jayshree Dave Parisha Katwa Joanne Freedman Vivienne Do Nascimento Hilary Kirkbride Marie Anne Chattaway Gauri Godbole Sooria Balasegaram Source Type: research

Validation of Pefloxacin for detection of fluoroquinolone (FQ) resistance among Salmonella Typhi with special reference to GyrB mutations
Conclusion. The pefloxacin disc can be used to detect FQ resistance among S. Typhi. This is the first report of validation of pefloxacin for detection of FQ resistance in S. Typhi mediated by GyrB mutation.PMID:34356003 | DOI:10.1099/jmm.0.001398
Source: Journal of Medical Microbiology - August 6, 2021 Category: Microbiology Authors: Shakila Banu Inayath Shobha Broor Ruchi Gupta Priti Agarwal Subhradeep Majumder Anupam Kumar Anveshi Rajni Gaind Source Type: research

Emergence of a multidrug-resistant plasmid encoding bla NDM-1 , bla OXA-420 and armA in a clinical isolate of Acinetobacter variabilis in Japan
J Med Microbiol. 2021 Aug;70(8). doi: 10.1099/jmm.0.001395.ABSTRACTAcinetobacter variabilis (formerly genospecies 15 sensu Tjernberg and Ursing) has been isolated from humans and animals and was proposed to be a novel species in 2015. A multidrug-resistant A. variabilis isolate, RYU24, was obtained in 2012 from an inpatient in Okinawa, Japan, with no record of overseas travel. The isolate was resistant to carbapenems, aminoglycosides and ciprofloxacin, with minimum inhibitory concentrations (MICs) of 32 µg ml-1 for imipenem and meropenem; > 1024 µg ml-1 for amikacin, arbekacin, gentamicin and tobramycin; and 8 µg ml-...
Source: Journal of Medical Microbiology - August 25, 2021 Category: Microbiology Authors: Kohei Uechi Mari Tohya Tatsuya Tada Takaaki Tome Ami Takahashi Takeshi Kinjo Shiro Maeda Teruo Kirikae Jiro Fujita Source Type: research

Molecular characterization of rectal isolates of carbapenemase-negative carbapenem-resistant enterobacterales obtained from ICU patients in Kuwait by whole-genome sequencing
Conclusions. This finding reflects the superior detection capabilities offered by WGS analysis, which can be used to complement traditional methods and overcome their limited resolution in clinical settings.PMID:34477546 | DOI:10.1099/jmm.0.001409
Source: Journal of Medical Microbiology - September 3, 2021 Category: Microbiology Authors: Amani Al Fadhli Wafaa Jamal Vincent O Rotimi Source Type: research

Evolution of fluoroquinolone-resistant Escherichia coli in the gut after ciprofloxacin treatment
CONCLUSION: No fitness, tolerance, metabolic or genomic evolution of commensal QREC was observed overtime, despite massive exposure to ciprofloxacin in the gut. The three strains behaved as if they had been unaffected by ciprofloxacin, suggesting that gut may act as a sanctuary where bacteria would be protected from the effect of antibiotics and survive without any detrimental effect of stress.PMID:35030401 | DOI:10.1016/j.ijmm.2022.151548
Source: International Journal of Medical Microbiology - January 14, 2022 Category: Microbiology Authors: V de Lastours I El Meouche F Chau J Beghain D Chevret A Aubert-Frambourg O Clermont G Royer O Bouvet E Denamur B Fantin CIPHARES Group Source Type: research

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