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Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
In conclusion, these findings suggested that moderate vitamin D supplementation rescued simvastatin induced myopathy via improving the mitochondrial cristae shape and function. PMID: 32479918 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - May 28, 2020 Category: Toxicology Authors: Ren L, Xuan L, Han F, Zhang J, Gong L, Lv Y, Zhang W, Yang S, Xu B, Yan Y, Guo L, Liu H, Wan Z, Liu L Tags: Toxicol Appl Pharmacol Source Type: research

Risk identification and possible countermeasures for muscle adverse effects during statin therapy.
Abstract The use of statins for cardiovascular disease prevention is clearly supported by clinical evidence. However, in January 2014 the U.S. Food and Drug Administration released an advice on statin risk reporting that "statin benefit is indisputable, but they need to be taken with care and knowledge of their side effects". Among them the by far most common complication is myopathy, ranging from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. This class side effect appears to be dose dependent, with more lipophilic statin (i.e., simvastatin) carrying a higher overall risk. Hence...
Source: European Journal of Internal Medicine - January 29, 2015 Category: Internal Medicine Authors: Magni P, Macchi C, Morlotti B, Sirtori CR, Ruscica M Tags: Eur J Intern Med Source Type: research

Low Vitamin D as a Risk Factor for the Development of Myalgia in Patients Taking High-Dose Simvastatin: A Retrospective Review.
CONCLUSION: A lower incidence of adverse muscle events with high-dose simvastatin 80 mg was found in patients with higher vitamin D levels, suggesting that correction of 25-hydroxyvitamin D levels before statin therapy initiation may mitigate one risk factor in the development of statin-related myalgia. Vitamin D insufficiency appears to be a risk factor for the development of myalgia. PMID: 24742497 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - April 14, 2014 Category: Drugs & Pharmacology Authors: Mergenhagen K, Ott M, Heckman K, Rubin LM, Kellick K Tags: Clin Ther Source Type: research