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Drug: Estradiol
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Total 6417 results found since Jan 2013.
Greb1 Transiently Accelerates Pancreatic β-Cell Proliferation in Diabetic Mice Exposed to Estradiol
Am J Pathol. 2023 Aug;193(8):1081-1100. doi: 10.1016/j.ajpath.2023.04.012.ABSTRACTDecrease of pancreatic β cells leads to diabetes. In an inducible cAMP early suppressor (ICER-Iγ) transgenic mouse model of severe type 2 diabetes with reduced insulin production and depleted β cells, supplementation with high concentrations of 17β-estradiol (E2) markedly enhances β-cell proliferation and normalizes glucose levels. The current study explored the underlying mechanisms leading to a dynamic increase of β cells and pathologic changes in diabetic mice exposed to E2. Gene expression profiling of pancreatic islets of 6-month-o...
Source: The American Journal of Pathology - July 29, 2023 Category: Pathology Authors: Akari Inada Yohichi Yasunami Atsushi Yoshiki Yo-Ichi Nabeshima Oogi Inada Source Type: research
Neonatal estrogen induces male-like expression of astroglial markers of maturation and plasticity in the neocortex of female mice
In this study, we investigated whether administration of perinatal estradiol to female mice is sufficient to masculinize astroglial protein and gene expression related to maturation that we previously observed at P7. We found that canonical astroglial markers like glial fibrillary acidic protein and glutamine synthetase are not affected by perinatal estrogen, but markers of astroglial maturation, Vimentin, Aldh1a1, Dio2, and the number of actively dividing astroglia are masculinized by perinatal estradiol administration. These findings suggest that sex differences in neocortical astroglial maturation are at least in-part d...
Source: Brain Research - July 27, 2023 Category: Neurology Authors: G M Rurak A Gahelrasoul A Aguilar-Valles N Salmaso Source Type: research
In vitro evaluation for estrogenic mechanisms of the disinfectant benzalkonium chloride as an emerging contaminant
This study aimed to evaluate in vitro the possible mechanisms underlying the estrogenic potential of benzalkonium chloride (BAC) as a disinfectant emerging contaminant. Effects of BAC at the environmentally-relevant concentrations on estrogen synthesis and estrogen receptor (ER) signaling were assessed using the H295R steroidogenesis assay and the MCF-7 proliferation assay, respectively. Results showed that exposure to BAC at concentrations of 1.0-1.5 mg/L for 48 h significantly increased estradiol production of H295R cells in a concentration-dependent manner. Transcription of steroidogenic genes 3β-HSD2, 17β-HSD1, 17β-...
Source: Braz J Med Biol Res - July 26, 2023 Category: Research Authors: Songyi Wei Xianmin Hu Xinyi Hu Yisheng Wan Guangquan Fan Jun Wang Source Type: research
Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and Infertility
This article is protected by copyright. All rights reserved.PMID:37493193 | DOI:10.1002/jcph.2318
Source: The Journal of Clinical Pharmacology - July 26, 2023 Category: Drugs & Pharmacology Authors: Ting-Ting Xia Ke-Fei Zeng Qing-Mei Peng Source Type: research
In vitro evaluation for estrogenic mechanisms of the disinfectant benzalkonium chloride as an emerging contaminant
This study aimed to evaluate in vitro the possible mechanisms underlying the estrogenic potential of benzalkonium chloride (BAC) as a disinfectant emerging contaminant. Effects of BAC at the environmentally-relevant concentrations on estrogen synthesis and estrogen receptor (ER) signaling were assessed using the H295R steroidogenesis assay and the MCF-7 proliferation assay, respectively. Results showed that exposure to BAC at concentrations of 1.0-1.5 mg/L for 48 h significantly increased estradiol production of H295R cells in a concentration-dependent manner. Transcription of steroidogenic genes 3β-HSD2, 17β-HSD1, 17β-...
Source: Braz J Med Biol Res - July 26, 2023 Category: Research Authors: Songyi Wei Xianmin Hu Xinyi Hu Yisheng Wan Guangquan Fan Jun Wang Source Type: research
