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Novel treatment of eosinophilic bronchitis with allergic fungal sinusitis using mepolizumab
Case ReportThis rare case report describes a patient with eosinophilic bronchitis with allergic fungal sinusitis treated with mepolizumab. A 29-year old man with a history of asthma complicated by eosinophilic sinusitis over 5 years was admitted to our hospital due to poor response to treatments, such as ICS/LABA/LAMA.The patient experienced a gradual worsening of asthma despite endoscopic sinus surgery which was conducted by the otolaryngology department. He was visiting the ER every two weeks, and was admitted to hospital once every month. Treatment response to asthma using methylprednisolone (PSL) 10mg/day and bronchial...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Takeshita, Y., Nobuyama, S., Satou, T. Tags: Allergy and immunology Source Type: research

Stratified premedication strategy for the prevention of contrast media hypersensitivity in high-risk patients.
CONCLUSION: In a total severity-based stratified prophylaxis regimens and changing iodinated contrast media can be considered in patients with a history of previous hypersensitivity reaction to iodinated contrast media to reduce the risk of breakthrough reactions. PMID: 28087383 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 9, 2017 Category: Allergy & Immunology Authors: Lee SY, Yang MS, Choi YH, Park CM, Park HW, Cho SH, Kang HR Tags: Ann Allergy Asthma Immunol Source Type: research

A cjd mimic; 'feeding ice-cream to her cats'
Conclusions Primary CNS lymphoma is a rare cause of cognitive decline and most commonly affects individuals who are immunosuppressed, however in immunocompetent individuals, increasing age is a major risk factor. In the elderly most cases are diffuse large B–cell lymphoma which can present with a vast array of symptoms; seizures, neuropsychiatric symptoms, altered mental state, focal neurological deficits and systemic symptoms of weight loss, fever and night sweats. Neuroimaging is often highly variable and may differ between those who are immunocompetent or immunosuppressed. Ultimately, the gold–standard test ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Shute, C., Johnston, A., Neal, J., Smith, P. Tags: Immunology (including allergy), Dementia, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Variant Creutzfeld-Jakob Disease, Neuropathology, Memory disorders (psychiatry), Radiology, Surgical diagnostic tests, Radiology (diagnos Source Type: research