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Drug: Methotrexate
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Total 45 results found since Jan 2013.
Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells
This study is the first report on co-delivery of MTX and STAT3 siRNA by chitosan modified MSNs.PMID:35132929 | DOI:10.1080/21691401.2022.2030746
Source: Artificial Cells, Nanomedicine and Biotechnology - February 8, 2022 Category: Biotechnology Authors: Zahra Shakeran Jaleh Varshosaz Mehrnaz Keyhanfar Hossein Mohammad-Beigi Karim Rahimi Duncan S Sutherland Source Type: research
Sinomenine increases adenosine A < sub > 2A < /sub > receptor and inhibits NF- κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR
J Leukoc Biol. 2021 Aug 23. doi: 10.1002/JLB.3MA0121-024RRRR. Online ahead of print.ABSTRACTSinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of SIN acting on α7nAChR and the effect on adenosine A2A receptor (A2A R) in RA are not clear. In the present study, the effects of SIN on adjuvant-induced-arthritis (AIA) rats in vivo and on fibroblast-like synoviocyte...
Source: Journal of Leukocyte Biology - August 23, 2021 Category: Hematology Authors: Lang Yi Junyu Ke Jiayan Liu Huili Lai Yanjun Lv Chong Peng Yingkun Zhi Qun Du Liang Liu Peixun Wang Hua Zhou Yan Dong Source Type: research
Genes, Vol. 12, Pages 1102: Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy
ati Nazhad Dolatabadi
The transcription factor high mobility group protein A2 (HMGA2) plays an important role in the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer generation 4 is a kind of highly branched polymeric nanoparticle with surface charge and highest density peripheral groups that allow ligands or therapeutic agents to attach it, thereby facilitating target delivery. Here, methotrexate (MTX)- modified polyamidoamine dendrimer generation 4 (G4) (G4/MTX) was generated to deliver specific small interface RNA (siRNA) for suppressing HMGA2 expression and the consequent effects on fo...
Source: Genes - July 20, 2021 Category: Genetics & Stem Cells Authors: Fereydoon Abedi Gaballu William Chi-Shing Cho Gholamreza Dehghan Amir Zarebkohan Behzad Baradaran Behzad Mansoori Soheil Abbaspour-Ravasjani Ali Mohammadi Nader Sheibani Ayuob Aghanejad Jafar Ezzati Nazhad Dolatabadi Tags: Article Source Type: research
