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Carbonic Anhydrase 1-Mediated Calcification Is Associated With Atherosclerosis, and Methazolamide Alleviates Its Pathogenesis
Vascular calcification is an important pathogenic process in atherosclerosis (AS); however, its immediate cause is unknown. Our previous study demonstrated that carbonic anhydrase 1 (CA1) stimulates ossification and calcification in ankylosing spondylitis and breast cancer. The current study investigated whether CA1 plays an important role in AS calcification and whether the CA inhibitor methazolamide (MTZ) has a therapeutic effect on AS. We successfully established an AS model by administration of a high-fat diet to ApoE-/- mice. The treated animals had significantly increased serum levels of high-density lipoprotein chol...
Source: Frontiers in Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Source Type: research

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
Abstract Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary concentrating defect. Li-NDI is due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Earlier, we have shown that the carbonic anhydrase (CA) inhibitor acetazolamide attenuated Li-induced downregulation in mouse collecting duct (mpkCCD) cells. Of the eight CAs present in mpkCCD cells, siRNA and drug treatments showed that downregulation of CA9 and to some ex...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Alsady M, de Groot T, Kortenoeven MLA, Carmone C, Neijman K, Bekkenkamp-Grovenstein M, Engelke U, Wevers R, Baumgarten R, Korstanje R, Deen PMT Tags: Am J Physiol Renal Physiol Source Type: research

CA1 contributes to microcalcification and tumourigenesis in breast cancer
Conclusion: The results of this study suggested that CA1 is a potential oncogene and that it contributes to abnormal cell calcification, apoptosis and migration in breast cancer.
Source: BMC Cancer - October 12, 2015 Category: Cancer & Oncology Authors: Yabing ZhengBing XuYan ZhaoHe GuChang LiYao WangXiaotian Chang Source Type: research