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Total 18 results found since Jan 2013.

Cancers, Vol. 12, Pages 3589: Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma
Danen Bovée Mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes are common in enchondromas and chondrosarcomas, and lead to elevated levels of the oncometabolite D-2-hydroxyglutarate causing widespread changes in the epigenetic landscape of these tumors. With the use of a DNA methylation array, we explored whether the methylome is altered upon progression from IDH mutant enchondroma towards high-grade chondrosarcoma. High-grade tumors show an overall increase in the number of highly methylated genes, indicating that remodeling of the methylome is associated with tumor progression. Therefore, an epigene...
Source: Cancers - November 30, 2020 Category: Cancer & Oncology Authors: Venneker Kruisselbrink Baranski Palubeckaite Briaire-de Bruijn Oosting French Danen Bov ée Tags: Article Source Type: research

Identification and Molecular Characterization of a Novel Hordeivirus Associated With Yellow Mosaic Disease of Privet (Ligustrum vulgare) in Europe
Wild plants serve as a large reservoir of known and yet-unknown viruses and as a source of viral pathogens of cultivated plants. Yellow mosaic disease of forest shrub Ligustrum vulgare (privet) was recurrently observed in Europe for more than 100 years. Using a universal virus identification approach based on deep sequencing and de novo assembly of viral small interfering (si)RNAs we identified a causative agent of this disease in Switzerland and reconstructed its complete 3-segmented RNA genome. Notably, a short 3′-terminal common region (CR) attached to each segment via a ∼53–71 nucleotide poly(A) tract, as determi...
Source: Frontiers in Microbiology - September 27, 2021 Category: Microbiology Source Type: research

Genes, Vol. 14, Pages 398: Suppressors of Break-Induced Replication in Human Cells
Michael Leffak Short tandem DNA repeats are drivers of genome instability. To identify suppressors of break-induced mutagenesis human cells, unbiased genetic screens were conducted using a lentiviral shRNA library. The recipient cells possessed fragile non-B DNA that could induce DNA double-strand breaks (DSBs), integrated at an ectopic chromosomal site adjacent to a thymidine kinase marker gene. Mutagenesis of the thymidine kinase gene rendered cells resistant to the nucleoside analog ganciclovir (GCV). The screen identified genes that have established roles in DNA replication and repair, chromatin modification, re...
Source: Genes - February 3, 2023 Category: Genetics & Stem Cells Authors: Stanley Dean Rider French J. Damewood Rujuta Yashodhan Gadgil David C. Hitch Venicia Alhawach Resha Shrestha Matilyn Shanahan Nathen Zavada Michael Leffak Tags: Article Source Type: research