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Effect of Disease Severity on Comorbid Conditions in Atopic Dermatitis: Nationwide Registry-Based Investigation in Finnish Adults
Acta Derm Venereol. 2023 Mar 8;103:adv00882. doi: 10.2340/actadv.v103.4447.ABSTRACTThe majority of registry studies on atopic dermatitis include only patients and diagnoses from specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate the effect of atopic dermatitis severity on comorbidities and total morbidity, with comprehensive data from both primary and specialty healthcare registries covering the entire Finnish adult population. In total, 124,038 patients were identified (median age 46 years; 68% female) and stratified by disease severity. All regression analyses (median follow-up...
Source: Acta Derm Venereol A... - March 8, 2023 Category: Dermatology Authors: Ville Kiiski Liisa Ukkola-Vuoti Johanna Vikkula Martta Ranta Mariann I Lassenius Jaakko Kopra Source Type: research

Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study
CONCLUSIONS: Severity determinants in Finnish patients seem to be early-onset, male sex, smoking, overweight, concomitant asthma, palmar hyperlinearity, hand dermatitis and high IgE-levels. A sub-typing of patients in relation to confirmed severity determinants may be useful for course prediction, prognosis, and targeted AD management.PMID:35766133 | DOI:10.1111/jdv.18378
Source: Herpes - June 29, 2022 Category: Infectious Diseases Authors: A Salava V Salo J Lepp änen A Lauerma A Remitz Source Type: research

A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research