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Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation
Infect Genet Evol. 2022 May 27:105310. doi: 10.1016/j.meegid.2022.105310. Online ahead of print.ABSTRACTNipah virus (NiV), a zoonotic virus, engenders severe infections with noticeable complications and deaths in humans and animals. Since its emergence, it is frightening that this virus has been causing regular outbreaks in various countries, particularly Bangladesh, India, and Malaysia. Unfortunately, no efficient vaccine or drug is available to combat this baneful virus. It employs the nucleocapsid protein in its genetic material encapsidation, which is a crucial for viral replication. The small interfering RNAs (siRNAs)...
Source: Infection, Genetics and Evolution - May 31, 2022 Category: Genetics & Stem Cells Authors: A M U B Mahfuz Md Arif Khan Emran Hossain Sajib Anamika Deb Shafi Mahmud Mahmudul Hasan Otun Saha Ariful Islam M Mizanur Rahaman Source Type: research

Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach
In this study, we attempted to design a siRNA molecule to silence the most suitable nucleocapsid(N) gene of SARS-CoV-2, which play a major role during viral pathogenesis, replication, encapsidation and RNA packaging. At first, 270 complete N gene sequences of different strains in Bangladesh of these viruses were retrieved from the NCBI database. Different computational methods were used to design siRNA molecules. A siRNA molecule was built against these strains using the SiDirect 2.0 server. Using Mfold and the OligoCalc server, the siRNA molecule was tested for its secondary structure and GC material. The Clustal Omega to...
Source: Computational Biology and Chemistry - May 13, 2021 Category: Bioinformatics Authors: Syed Shahariar Bappy Abu Zaffar Shibly Sorna Sultana A K M Mohiuddin Yearul Kabir Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research