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Study protocol of a phase 2, dual-centre, randomised, controlled trial evaluating the effectiveness of probiotic and egg oral immunotherapy at inducing desensitisation or sustained unresponsiveness (remission) in participants with egg allergy compared with placebo (Probiotic Egg Allergen Oral Immunotherapy for Treatment of Egg Allergy: PEAT study)
This study has been approved by the Human Research Ethics Committees at the Royal Children’s Hospital (HREC 2019.082) and the National Healthcare Group Domain Specific Review Board (2019/00029). Results will be published in peer-reviewed journals and disseminated via presentations at international conferences. Trial registration number ACTRN12619000480189.
Source: BMJ Open - July 7, 2021 Category: General Medicine Authors: Loke, P., Chebar Lozinsky, A., Orsini, F., Wong, L. S.-Y., Leung, A. S.-Y., Tham, E. H., Lopata, A. L., Shek, L. P.-C., Tang, M. L., PEAT study team, Su, Robinson, Tey, Belousoff, Pitkin, Axelrad, Mitra, Chan, Yi, Ng Tags: Open access, Immunology (including allergy) Source Type: research

Keeping Athletes Healthy at the 2020 Tokyo Summer Games: Considerations and Illness Prevention Strategies
Conclusion It is apparent that athletes will be exposed to various stressors during both the preparatory and competition phases of the Summer Games. Athletes residing in the southern hemisphere appear to be at increased risk for illness during the preparatory phase, while female, Paralympic, water-sport and multi-competition/event athletes may be more susceptible to illness during the competition phase of the Summer Games. To maintain athlete health, illness prevention strategies should be targeted to stressors and at-risk athletes. Keeping athletes healthy will contribute to optimal Olympic and Paralympic athletic perfor...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

A New Peanut Allergy Drug Could Be a Promising Treatment for Children
A new drug could become the first-ever protective treatment for the more than one million children in the U.S. who suffer from peanut allergies. In a phase-three trial, the results of which were published in the New England Journal of Medicine, the peanut-derived drug AR101 helped some children with severe peanut allergies tolerate the equivalent of two peanut kernels without serious side effects. Prior to taking the drug, none of these children could safely ingest more than the equivalent of one-tenth of a kernel. AR101, which is manufactured by Aimmune Therapeutics (the company also designed and funded the study), delive...
Source: TIME: Health - November 19, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime Research Source Type: news

Scientists tout positive findings in peanut allergy pill study
Scientists in Australia report success with trials of a pill filled with a mix of probiotics and tiny amounts of peanut to build tolerance to peanut allergies.
Source: ABC News: Health - August 17, 2017 Category: Consumer Health News Tags: Health Source Type: news

Peanut allergy researchers say they may have found key to a cure
Melbourne-based study of children given nut protein with probiotic has transformed the lives of 80% of those who took part in clinical trialAustralian researchers have found a possible key to a cure for people with potentially fatal peanut allergies.A Melbourne-based study has already transformed the lives of many of the children who took part in the clinical trial.Continue reading...
Source: Guardian Unlimited Science - January 28, 2015 Category: Science Authors: Australian Associated Press Tags: Medical research Allergies Health Science Melbourne Australia news World news Source Type: news