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Specialty: Cardiology
Condition: Disability
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Total 417 results found since Jan 2013.
Diabetes and Stroke: What Are the Connections?
J Stroke. 2023 Jan 3. doi: 10.5853/jos.2022.02306. Online ahead of print.ABSTRACTStroke is a major cause of death and long-term disability worldwide. Diabetes is associated with an increased risk of cardiovascular complications, including stroke. People with diabetes have a 1.5-2 times higher risk of stroke compared with people without diabetes, with risk increasing with diabetes duration. These risks may also differ according to sex, with a greater risk observed among women versus men. Several mechanisms associated with diabetes lead to stroke, including large artery atherosclerosis, cerebral small vessel disease, and car...
Source: Atherosclerosis - January 2, 2023 Category: Cardiology Authors: Ofri Mosenzon Alice Yy Cheng Alejandro A Rabinstein Simona Sacco Source Type: research
Intravenous Thrombolytics in the Treatment of Acute Ischemic Stroke
AbstractPurpose of ReviewTo review the current evidence and ongoing clinical trials evaluating the efficacy and safety of tenecteplase (TNK), an alternative tissue plasminogen activator (tPA), in the acute management of arterial ischemic stroke (AIS). To date, alteplase is the only tPA approved by the United States FDA for use in AIS.Recent FindingsThere have been multiple phase two and three trials investigating the safety and efficacy of TNK in AIS. In patients with AIS due to large vessel occlusion, one randomized controlled trial demonstrated superiority of TNK for vessel recanalization rates and long-term functional o...
Source: Current Treatment Options in Cardiovascular Medicine - January 2, 2023 Category: Cardiology Source Type: research
The Global Burden of Peripheral Artery Disease
CONCLUSION: The global prevalence and mortality associated with PAD has increased substantially, in contrast to other forms of ischemic cardiovascular disease. Globally there is a growing need for vascular surgical resources to manage PAD, as well as public health efforts to address risk factors for this increasing health threat.PMID:36565779 | DOI:10.1016/j.jvs.2022.12.015
Source: Atherosclerosis - December 24, 2022 Category: Cardiology Authors: Mark A Eid Kunal Mehta J Aaron Barnes Zachary Wanken Jesse A Columbo David H Stone Philip Goodney Michael Mayo Smith Source Type: research
microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective
Int J Mol Sci. 2022 Dec 9;23(24):15645. doi: 10.3390/ijms232415645.ABSTRACTIschemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could ...
Source: Atherosclerosis - December 23, 2022 Category: Cardiology Authors: Rafa ł Badacz Tadeusz Przew łocki Jacek Legutko Krzysztof Żmudka Anna Kab łak-Ziembicka Source Type: research
Influence of Management of Intensive Weight, Blood Pressure, and Lipids on Disease Severity in Patients with Carotid Atherosclerosis
CONCLUSIONS: A program for management of body weight, blood pressure, and blood lipids can effectively control the severity of carotid atherosclerosis, can prevent the disease's progression, and can be promoted as a clinical application.PMID:36455146
Source: Atherosclerosis - December 1, 2022 Category: Cardiology Authors: Yongjian Liu Xiaojing Yan Jin Zhou Litao Chen Zhixing Du Jianmin Pang Liya Jiao Dan Li Yongmin Deng Source Type: research
Correlation between Lpa, APO-A, APO-B, and Stenosis of Middle Cerebral Artery in Patients with Cerebral Ischemic Stroke
This study retrospectively collected the case data of 186 patients with CIS treated from May 2020 to May 2022 and explored the correlation between Lpa, APO-A, APO-B, and middle cerebral artery (MCA) stenosis in CIS patients.PMID:36419955 | PMC:PMC9678485 | DOI:10.1155/2022/6403645
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Xinxu Chen Xuefei Lu Wei Li Hongyan Zhang Tan Wang Source Type: research
World Heart Federation Cholesterol Roadmap 2022
CONCLUSIONS: The adverse effects of LDL-cholesterol and apo B containing lipoprotein exposure are cumulative and result in ASCVD. These are preventable by implementation of different strategies, aimed at efficiently tackling atherosclerosis at different stages throughout the human life-course. Preventive strategies should therefore be updated to implement health policy, lifestyle changes and when needed pharmacotherapies earlier with investment in, and a shift in focus towards, early preventive strategies that preserve cardiovascular health rather than treat the consequences of ASCVD.PMID:36382159 | PMC:PMC9562775 | DOI:10.5334/gh.1154
Source: Atherosclerosis - November 16, 2022 Category: Cardiology Authors: Kausik K Ray Brian A Ference Tania S éverin Dirk Blom Stephen J Nicholls Mariko H Shiba Wael Almahmeed Rodrigo Alonso Magdalena Daccord Marat Ezhov Rosa Fern ández Olmo Piotr Jankowski Fernando Lanas Roopa Mehta Raman Puri Nathan D Wong David Wood Dong Source Type: research
Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders
CONCLUSION: The emergence of miRNAs as pathological regulatory factors provides a new direction for the study of bioactive compounds in Traditional Chinese medicine and the elucidating of their epigenetic effects. Elucidating the regulatory relationship between bioactive compounds and miRNAs may help to identify new therapeutic targets and promoting the application of these compounds in precision medicine through their targeted molecular activity.PMID:36368284 | DOI:10.1016/j.phymed.2022.154501
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Xiaoyu Dong Jianfei Nao Source Type: research
Exercise for the Prevention of Anthracycline-induced Functional Disability and Cardiac Dysfunction: The BReast Cancer Randomized EXercise InTervention (BREXIT) Study
Conclusions: In women with early-stage BC undergoing AC, 12-months of ExT did not attenuate functional disability but provided large and clinically meaningful benefits on VO2peak and cardiac reserve. Clinical Trial Registration: URL: https://www.anzctr.org.au/ Unique Identifier: ACTRN12617001408370.PMID:36342348 | DOI:10.1161/CIRCULATIONAHA.122.062814
Source: Circulation - November 7, 2022 Category: Cardiology Authors: Stephen J Foulkes Erin J Howden Mark J Haykowsky Yoland Antill Agus Salim Sophie S Nightingale Sherene Loi Piet Claus Kristel Janssens Amy M Mitchell Leah Wright Ben T Costello Anniina Lindqvist Lauren Burnham Imogen Wallace Robin M Daly Steve F Fraser An Source Type: research
