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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Disability
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Total 286 results found since Jan 2013.
Utilization and Outcomes of Acute Revascularization Treatment in Ischemic Stroke Patients with SARS-CoV-2 Infection
Our understanding of outcomes in acute ischemic stroke patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection following acute revascularization treatments (as intravenous thrombolysis and/or thrombectomy) is based on small case series.1-3. An international panel4 cautioned regarding the potential for high rate of death or disability and post thrombolytic intracerebral hemorrhage (ICH)s in acute ischemic stroke patients with SARS-CoV-2 infection due to elevated concentrations of inflammation and hypercoagulability markers such as leukocytosis, and C reactive protein and D dimers and multisystem dysfunction.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2021 Category: Neurology Authors: Adnan I. Qureshi, William I. Baskett, Wei Huang, Muhammad F. Ishfaq, S. Hasan Naqvi, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Chi-Ren Shyu Tags: SARS-CoV-2 and acute revascularization Source Type: research
Utilization and Outcomes of Acute Revascularization Treatments in Ischemic Stroke Patients with SARS-CoV-2 Infection
Our understanding of outcomes in acute ischemic stroke patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection following acute revascularization treatments (as intravenous thrombolysis and/or thrombectomy) is based on small case series.1 –3 An international panel4 cautioned regarding the potential for high rate of death or disability and post thrombolytic intracerebral hemorrhage (ICH)s in acute ischemic stroke patients with SARS-CoV-2 infection due to elevated concentrations of inflammation and hypercoagulability markers such as leukocytosis, and C reactive protein and D dimers and multisystem dysfunction.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2021 Category: Neurology Authors: Adnan I. Qureshi, William I. Baskett, Wei Huang, Muhammad F. Ishfaq, S. Hasan Naqvi, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Chi-Ren Shyu Source Type: research
How to Score the Peak Oxygen Consumption Obtained Through Cardiopulmonary Exercise Test in Individuals after Stroke?
Stroke is considered one of the main causes of disability worldwide.1 Individuals after stroke usually show reduced cardiorespiratory fitness as well as exercise capacity2-6 which are associated to limitations on activities of daily life.7-9
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2022 Category: Neurology Authors: Ludmylla Ferreira Quintino, Larissa Tavares Aguiar, Sherindan Ayessa Ferreira de Brito, Maria Teresa Ferreira dos Reis, Janaine Cunha Polese, Christina Danielli Coelho de Morais Faria Source Type: research
Cerebral Infarction due to Severe ADAMTS-13 Deficiency with Normal Hematological Parameters: A Cause of Cryptogenic Stroke
Stroke is a leading cause of death and disability worldwide, and there are 1.3 million strokes annually in adults less than 50 years old.1 Many of these strokes are cryptogenic, with no clear etiology identified. In this setting clinicians frequently test for rare causes of thrombosis including hyperhomocystinemia, antiphospholipid syndrome, Factor V Leiden, prothrombin gene mutations, and protein C, S or antithrombin deficiency. Thrombotic thrombocytopenic purpura (TTP) causes arterial thrombosis, but is rarely considered in the evaluation of cryptogenic stroke with normal or near-normal hematologic profiles.
Source: Journal of Stroke and Cerebrovascular Diseases - March 16, 2022 Category: Neurology Authors: Andrew Matthews, Jennifer Yui, Elaine Y. Chiang, Allyson M. Pishko, Adam Cuker, Brett L. Cucchiara, Donna George, Farzana Sayani, Michael T. Mullen Tags: Short Communication Source Type: research
Revisiting dose and intensity of training: Opportunities to enhance recovery following stroke
Stroke is a global leading cause of adult disability with survivors often enduring persistent impairments and loss of function. Both intensity and dosage of training appear to be important factors to help restore behavior. However, current practice fails to achieve sufficient intensity and dose of training to promote meaningful recovery. The purpose of this review is to propose therapeutic solutions that can help achieve a higher dose and/or intensity of therapy. Raising awareness of these intensive, high-dose, treatment strategies might encourage clinicians to re-evaluate current practice and optimize delivery of stroke r...
Source: Journal of Stroke and Cerebrovascular Diseases - September 23, 2022 Category: Neurology Authors: Kalita Donnellan-Fernandez, Andrew Ioakim, Brenton Hordacre Source Type: research
Inhibition of PI3K/Akt/mTOR signaling by NDRG2 contributes to neuronal apoptosis and autophagy in ischemic stroke
Stroke is the third cause of death worldwide and the major cause of severe adult disability, and ischemic stroke (IS) is the most frequent type in clinic 1. Autophagy, a self-eating cellular catabolic pathway, has been reported to be activated in various cells in the brain, such as neurons, glia cells, and brain microvascular cells upon IS 2. However, the molecular mechanisms of autophagy that are implicated in IS have yet to be elucidated. Autophagy is particularly important in neurons, and there are both constitutive and stress-induced pathways that catalyze the turnover of aged or damaged mitochondria, endoplasmic retic...
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2023 Category: Neurology Authors: Yuanyuan Wang, Bo Wang, Yuanyuan Liu, Yansong Guo, Hui Lu, Xiqi Liu Source Type: research
NOMINAL CONTRIBUTION OF LOW AND LOWER-MIDDLE- INCOME COUNTRIES (LMICs) IN MAJOR CLINICAL TRIALS ON SECONDARY STROKE PREVENTION: IMPLICATIONS FOR GUIDELINE DEVELOPMENT
Approximately 90% of all stroke deaths and disabilities occur in LMICs where implementation of secondary prevention is constrained. Clinicians in LMIC settings depend on stroke guidelines emanating from high-income countries developed largely using clinical trial data with minimal contribution of study participants from LMICs.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: Priscilla Abrafi Opare-Addo, Fred Stephen Sarfo, Patrick Opoku Berchie, Bruce Ovbiagele Source Type: research
The level of stroke severity amongst early and late presenters and their functional outcomes during a 30-day period in a teaching hospital in ghana
This study aimed at examining the clinical presentation of patients with acute ischaemic stroke, who presented early ( 4.5 hrs) against their functional outcomes during a 30-day period.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2023 Category: Neurology Authors: F. Duodu, D. Brodie Mends, P. Pekyi-Boateng, B. Agbinko-Djobalar, J. Abugre, P. Adjei, A Akpalu, K Nkromah Source Type: research
Autonomic function may mediate the neuroprotection of remote ischemic postconditioning in stroke: A randomized controlled trial
Acute ischemic stroke(AIS) is one of the leading causes of death and long-lasting disability on a global level, with an increased global burden in the past two decades.1,2 Early restoration of blood flow is currently recognized as the most effective therapy for AIS. However, rapid reperfusion after a certain period of ischemia could paradoxically induce ischemia-perfusion injury (IRI), which can promote neurovascular inflammation by inducing the generation of cytokines, and thus aggravate stroke severity and adverse neurological outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 15, 2023 Category: Neurology Authors: Hao Liang, Richun Ye, Xiaopei Zhang, Huanwen Ye, Wenwei Ouyang, Shuang Cai, Lin Wei Source Type: research
Klotho gene might antagonize ischemic injury in stroke rats by reducing the expression of AQP4 via P38MAPK pathway
Epidemiological studies have shown that ischemic stroke (IS) is a disease with high morbidity, disability, and mortality. Approximately 16.9 million people suffer from IS, and 2.7 million die from this disease each year worldwide; 50% of survivors are disabled, putting a heavy financial burden on patients' families and society.1 Ischemic stroke is caused by a series of harmful signal cascade reactions triggered by a sudden interruption of blood supply to brain tissue, resulting in irreversible brain tissue damage and neurological impairments.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2023 Category: Neurology Authors: Guanghua Zhu, Tao Xiang, Shengjiao Liang, Kai Liu, Zijian Xiao, Qing Ye Source Type: research
Social and health determinants related to adverse short-term outcomes after a first-ever stroke in adults younger than 65 years
Stroke-related mortality and disability-adjusted life years in adults younger than 65 have increased over the last decade. However, geographical differences in distributing these outcomes could reflect dissimilarity in determinants. Therefore, this cross-sectional study of secondary data from Chilean hospitals aims to analyze the association of sociodemographic and clinical factors with in-hospital case-fatality risk or acquired neurologic deficits (adverse outcomes) in inpatients aged 18 to 64 who experienced their first-ever stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2023 Category: Neurology Authors: Mauricio Lopez-Espejo, Rodrigo Poblete, Gabriel Bastias Source Type: research
Risk of suicide among stroke survivors in the United States
Stroke is the largest cause of disability and the 5th leading cause of death in the United States. Suicide is the 12th leading cause of death in the United States. However, little is known about the risk of suicide among people with a prior stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2023 Category: Neurology Authors: Ben Grobman, Neeharika Kothapalli, Arian Mansur, Christine Y Lu Source Type: research
Toward a Modern Delivery of Stroke Care in Emerging Economies
Noncommunicable diseases are now a major source of mortality and disability in the developing world. Stroke incidence and prevalence is on the rise and is of particular interest because of its elevated mortality and morbidity. Developing countries bear the brunt of this disease, which hampers efforts to achieve economic and societal growth. Effective strategies to control this disease should focus on prevention without neglecting acute therapies.
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2012 Category: Neurology Authors: Felipe de los Ríos la Rosa, Joseph P. Broderick Tags: Review Articles Source Type: research
Efficacy of Bisphosphonates against Hip Fracture in Elderly Patients with Stroke and Parkinson Diseases: Meta-analysis of Randomized Controlled Trials
Stroke and Parkinson disease cause disability and immobilization that increase the risk for fractures. The purpose of the present research was to clarify the efficacy of 3 different bisphosphonates against hip fracture in elderly patients with these neurologic diseases. A literature search was performed in Medline, Embase, CBMdisc, and the Cochrane Library until March 1, 2014, with respect to strictly conducted randomized controlled trials (RCTs) and a meta-analysis was conducted. Every study was evaluated using the Jadad scale.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2014 Category: Neurology Authors: Weiwei Zhang, Chen Zhu, Mengwen Sun, Yuhao Ge, Guang Yan Source Type: research
Gene Polymorphism of rs556621 but Not rs11984041 is Associated with the Risk of Large Artery Atherosclerotic Stroke in a Xinjiang Uyghur Population
Stroke is one of the main causes of death and adult chronic disability. Recently, 2 independent genome-wide association studies reported that the genetic variants (rs556621 and rs11984041) are significantly associated with large artery atherosclerosis (LAA).
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Jia Liu, Zhongyang Hu, Ru Chen, Heng Yang, Wen Zheng, Ding Liu, Chen Zhang, Hao Deng, Qian Wang, Jiaqi Yin, Zhi Song Source Type: research
