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Maternal vitamin D –related metabolome and offspring risk of asthma outcomes
Vitamin D deficiency in childhood has been associated with various adverse health consequences as 25-hydroxyvitamin D (25(OH)D) possesses a range of immune regulatory properties with potential implications for proneness to respiratory infection, allergies, and asthma.1,2 Studies have further shown that 25(OH)D deficiency during pregnancy may affect fetal immune programming, consequently increasing the risk of asthma in early childhood.3,4 Therefore, we recently performed an intervention study in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort,5 which showed beneficial effects of high-dose...
Source: Journal of Allergy and Clinical Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Min Kim, Nicklas Brustad, Mina Ali, G özde Gürdeniz, Morten Arendt, Augusto A. Litonjua, Craig E. Wheelock, Rachel S. Kelly, Yulu Chen, Nicole Prince, Feng Guo, Xiaobo Zhou, Jakob Stokholm, Klaus Bønnelykke, Scott T. Weiss, Hans Bisgaard, Jessica Lasky Source Type: research

Maternal vitamin D-related metabolome and offspring risk of asthma outcomes
In two independent birth cohorts, high-does vitamin D exposure during pregnancy reduced a risk of developing recurrent wheeze and acute wheeze exacerbations in offspring via sphingomyelin enriched metabolic profile.
Source: Journal of Allergy and Clinical Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Min Kim, Nicklas Brustad, Mina Ali, G özde Gürdeniz, Morten Arendt, Augusto A. Litonjua, Craig E. Wheelock, Rachel S. Kelly, Yulu Chen, Nicole Prince, Feng Guo, Xiaobo Zhou, Jakob Stokholm, Klaus Bønnelykke, Scott T. Weiss, Hans Bisgaard, Jessica Lasky Source Type: research

Primary Prevention of Allergy - Is It Feasible?
Allergy Asthma Immunol Res. 2023 Jul;15(4):419-436. doi: 10.4168/aair.2023.15.4.419.ABSTRACTThe allergy epidemic has been attributed to environmental influences related to urbanization and the modern lifestyle. In this regard, various theories exploring the role of microbes (hygiene, old friends, microbiota, and biodiversity hypotheses), and the epithelial barrier (epithelial, dual allergen exposure and vitamin D hypotheses) have been proposed. These hypotheses have guided clinical studies that led to the formulation of intervention strategies during the proposed window of opportunity dubbed as the "first thousand days." T...
Source: Allergy, Asthma and Immunology Research - July 20, 2023 Category: Allergy & Immunology Authors: Pauline Poh-Lin Chan Ng Elizabeth Huiwen Tham Bee-Wah Lee Source Type: research

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